3 documents found, page 1 of 1
Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia...
Silva, Ana; Almeida, Afonso; Cachucho, Ana; Neto, João Luís; Demeyer, Sofie; Ramos De Matos, Mafalda; Hogan, Thea; Li, Yunlei; Meijerink, JulesTight regulation of IL-7Rα expression is essential for normal T-cell development. IL-7Rα gain-of-function mutations are known drivers of T-cell acute lymphoblastic leukemia (T-ALL). Although a subset of patients with T-ALL display high IL7R messenger RNA levels and cases with IL7R gains have been reported, the impact of IL-7Rα overexpression, rather than mutational activation, during leukemogenesis remains uncl...
Flip the coin: IL-7 and IL-7R in health and disease
Barata, João T.; Durum, Scott K.; Seddon, BenedictThe cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell development, as well as differentiation and survival of naive T cells, and generation and maintenance of memory T cells. They are also required for innate lymphoid cell (ILC) development and maintenance, and consequently for generation of lymphoid structures and barrier defense. Here we discuss the central role of IL-7 ...
The basic leucine zipper transcription factor E4BP4 is essential for natural ki...
Gascoyne, Duncan M.; Long, Elaine; Veiga-Fernandes, Henrique; de Boer, Jasper; Williams, Owen; Seddon, Benedict; Coles, Mark; Kioussis, DimitrisNatural killer (NK) cells are a subset of lymphocytes crucial for innate immunity and modification of adaptive immune responses. In contrast to commitment to the T cell or B cell lineage, little is known about NK cell lineage commitment. Here we show that the basic leucine zipper (bZIP) transcription factor E4BP4 (also called NFIL3) is essential for generation of the NK cell lineage. E4BP4-deficient mice (Nfil3...