9 documents found, page 1 of 1
Kinetics of radium-223 and its effects on survival, proliferation and DNA damag...
Marques, IA; Abrantes, AM; Pires, AS; Neves, AR; Caramelo, FJ; Rodrigues, T; Matafome, P; Tavares-da-Silva, E; Gonçalves, AC; Pereira, CC; Teixeira, JPBackground Metastatic castration-resistant prostate cancer (mCRPC) is associated with a very unfavorable prognosis. At this advanced stage of the disease, there are several therapeutic strategies approved in recent times, being one of them Radium-223 dichloride (Radium-223). However, its mechanisms of action and the process that conducts to cell death are not fully understood. Given this, our main goal is to ch...
Association between Adipokines and Biomarkers of Alzheimer's Disease: A Cross-S...
Letra, L; Matafome, P; Rodrigues, T; Duro, D; Lemos, R; Baldeiras, I; Patrício, M; Castelo-Branco, M; Caetano, G; Seiça, R; Santana, IBACKGROUND: Adipose tissue dysfunction has been implicated in the pathophysiology of Alzheimer's disease. However, the involvement of adipokines, particularly adiponectin, remains unclear. OBJECTIVE: To compare serum and cerebrospinal fluid (CSF) levels of adiponectin, leptin and leptin-to-adiponectin ratio in patients within the spectrum of Alzheimer's disease and evaluate their relationship with classical bio...
Comparison of ELISA and HPLC-MS methods for the determination of exenatide in b...
Pinho, A; Fortuna, A; Falcão, A; Santos, AC; Seiça, R; Estevens, C; Veiga, F; Ribeiro, AThe development of biotechnology-based active pharmaceutical ingredients, such as GLP-1 analogs, brought changes in type 2 diabetes treatment options. For better therapeutic efficiency, these active pharmaceutical ingredients require appropriate administration, without the development of adverse effects or toxicity. Therefore, it is required to develop several quantification methods for GLP-1 analogs products, ...
ECM-enriched alginate hydrogels for bioartificial pancreas: an ideal niche to i...
Crisóstomo, J; Pereira, AM; Bidarra, SJ; Gonçalves, AC; Granja, PL; Coelho, JFJ; Barrias, CC; Seiça, RIntroduction: The success of a bioartificial pancreas crucially depends on ameliorating encapsulated beta cells survival and function. By mimicking the cellular in vivo niche, the aim of this study was to develop a novel model for beta cells encapsulation capable of establishing an appropriate microenvironment that supports interactions between cells and extracellular matrix (ECM) components. Methods: ECM compo...
Obesity as a risk factor for Alzheimer's disease: the role of adipocytokines
Letra, L; Santana, I; Seiça, RAlzheimer's disease is the leading cause of dementia and the most prevalent neurodegenerative disease. It is an aging-related multi-factorial disorder and growing evidence support the contribution of metabolic factors to what was formerly thought to be a centrally mediated process. Obesity has already been recognized as an important player in the pathogenesis of this type of dementia, independently of insulin r...
Pro-inflammatory triggers in childhood obesity: correlation between leptin, adi...
Pires, A; Martins, P; Pereira, AM; Marinho, J; Vaz Silva, P; Marques, M; Castela, E; Sena, C; Seiça, RINTRODUCTION: Pediatric obesity is increasingly prevalent in the Portuguese population. Adipocyte dysfunction results in the expression of pro-inflammatory mediators that are responsible for the low-grade inflammatory process that characterizes obesity. OBJECTIVES: The aim of this study was to investigate the relationship between markers of adiposity, inflammation and adipokines in a Portuguese obese pediatric ...
Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high...
Sena, CM; Louro, T; Matafome, P; Nunes, E; Monteiro, P; Seiça, RDiabetes mellitus is characterized by oxidative stress, which in turn determines endothelial dysfunction. Gliclazide is a sulphonylurea antidiabetic drug with antioxidant effects due to its azabicyclo-octyl ring. It has been reported to potentially protect the vasculature through improvements in plasma lipid levels and platelet function. We hypothesized that gliclazide has a beneficial effect on endothelial fun...
A role for atorvastatin and insulin combination in protecting from liver injury...
Matafome, P; Nunes, E; Louro, T; Amaral, C; Crisóstomo, J; Rodrigues, L; Moedas, AR; Monteiro, P; Cipriano, MA; Seiça, RNon-alcoholic fatty liver disease (NAFLD) is a major complication linked with the metabolic syndrome associated with dyslipidemia, inflammation, and oxidative stress. Impact of type 2 diabetes with hyperlipidemia in NAFLD has to be established, as well as the utility of commonly prescribed anti-diabetic and lipid-lowering agents in improving liver injury markers. Genetic type 2 diabetic Goto-Kakizaki rats were ...
Histological changes and impairment of liver mitochondrial bioenergetics after ...
Palmeira, CM; Ferreira, FM; Rolo, AP; Oliveira, PJ; Santos, MS; Moreno, AJ; Cipriano, MA; Martins, MI; Seiça, RThis study was designed to evaluate the effects of long-term treatment with alpha-naphthyl-isothiocyanate (ANIT) on liver histology and at the mitochondrial bioenergetic level. Since, ANIT has been used as a cholestatic agent and it has been pointed out that an impairment of mitochondrial function is a cause of hepatocyte dysfunction leading to cholestatic liver injury, serum markers of liver injury were measur...