4 documents found, page 1 of 1
Polyvinyl alcohol/chitosan wound dressings loaded with antiseptics
Massarelli, E.; Silva, D.; Pimenta, A. F. R.; Fernandes, A.I.; Mata, J. L. G.; Armês, H.; Salema-Oom, Madalena; Saramago, B.; Serro, A.P.Wound care remains a challenge in healthcare. This work aimed to develop a new polyvinyl alcohol (PVA)/chitosan (Ch) based wound dressing able to ensure protection, hydration and a controlled release of antiseptics, as alternative to actual treatments. Two distinct formulations (1:1 and 3:1, w/w) were prepared, sterilized by autoclaving and characterized concerning surface morphology, degradation over the time,...
Controlled release of moxifloxacin from intraocular lenses modified by Ar plasm...
Pimenta, Andreia; Vieira, Ana Paula; Colaco, Rogério; Saramago, Benilde; Gil, Maria; Coimbra, Patrícia; Alves, Patrícia; Bozukova, DimitriyaIntraocular lenses (IOLs) present an alternative for extended, local drug delivery in the prevention of post-operative acute endophthalmitis. In the present work, we modified the surface of a hydrophilic acrylic material, used for manufacturing of IOLs, through plasma-assisted grafting copolymerization of 2-acrylamido-2-methylpropane sulfonic acid (AMPS) or [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammo...
Controlled drug release from hydrogels for contact lenses: drug partitioning an...
Pimenta, A.F.R.; Ascenso, J.; Fernandes, J.C.S.; Colaço, R.; Serro, A.P.; Saramago, B.Optimization of drug delivery from drug loaded contact lenses assumes understanding the drug transport mechanisms through hydrogels which relies on the knowledge of drug partition and diffusion coefficients. We chose, as model systems, two materials used in contact lens, a poly-hydroxyethylmethacrylate (pHEMA) based hydrogel and a silicone based hydrogel, and three drugs with different sizes and charges: chlorh...
Tribological behavior of unveneered and veneered lithium disilicate dental mate...
Figueiredo-Pina, C. G.; Patas, N.; Canhoto, J.; Cláudio, R.; Olhero, S.M.; Serro, A.P.; Ferro, A.C.; Guedes, M.The friction and wear behaviour of a lithium disilicate dental ceramic against natural dental enamel is studied, including the effect of the presence of a fluorapatite veneering upon the tribological properties of the material. The tribological behaviour was assessed using reciprocating pin-on-plate test configuration, at pH 3 and pH 7. The surface energy of the plates was determined, as well as the zeta potent...