5 documents found, page 1 of 1
Evolution of Escherichia coli strains under competent or compromised adaptive i...
Ameline, Camille; Seixas, Elsa; Barreto, Hugo C.; Frazão, Nelson; Rodrigues, Miguel V.; Ventura, M. Rita; Lourenço, Marta; Gordo, IsabelFunding Information: Funding was provided by the project PTDC/BIA-EVL/7546/2020, from the Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia (FCT) to I.G, NF and ES. CA is funded by a Swiss National Science Foundation (SNSF) Postdoc.Mobility fellowship P500PB_206642, NF by the work contract IGC-DL57NT-26, under the contract-program between FCT, and ES by Project PTDC/BIA-EVL/7546/2020 from FCT. H.C.B. was supp...
A hypometabolic defense strategy against malaria
Ramos, Susana; Ademolue, Temitope W; Jentho, Elisa; Wu, Qian; Guerra, Joel; Martins, Rui; Pires, Gil; Weis, Sebastian; Carlos, Ana Rita; Mahú, InêsFunding Information: We thank Dr. Silvia Portugal (Max Plank Institute, Berlin) and Dr. Jessica Thompson (Instituto Gulbenkian de Ciência; IGC) for their critical review of the manuscript; Dr. Joanne Thompson (University of Edinburgh) for PcAS-GFPML parasites; BEI Resources for P. falciparum parasites (MRA-1029, deposited by Andrew M. Talman and Robert E. Sinden); and excellent support from IGC's Advanced Imagi...
Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection...
Santos, António M.; Lopes, Teresa; Oleastro, Mónica; Gato, Inês Vale; Floch, Pauline; Benejat, Lucie; Chaves, Paula; Pereira, Teresa; Seixas, ElsaThis project was funded by PTDC/SAU-OSM/66323/2006 and SFRH/BPD/34094/2006 research grants from the Fundacao para a Ciencia e a Tecnologia (FCT), Portugal.; Helicobacter pylori (H. pylori) infection triggers a sequence of gastric alterations starting with an inflammation of the gastric mucosa that, in some cases, evolves to gastric cancer. Efficient vaccination has not been achieved, thus it is essential to fin...
Rab and Arf Proteins in Genetic Diseases
Seixas, Elsa; Barros, Mafalda; C Seabra, Miguel; C. Barral, DuarteRab and ADP-ribosylation factor (Arf) family proteins are master regulators of membrane trafficking and are involved in all steps of vesicular transport. These families of small guanine-nucleotide-binding (G) proteins are well suited to regulate membrane trafficking processes since their nucleotide state determines their conformation and the capacity to bind to a multitude of effectors, which mediate their func...
Thousands of Rab GTPases for the cell biologist
Diekmann, Yoan; Seixas, Elsa; Gouw, Marc; Tavares-Cadete, Filipe; C Seabra, Miguel; Pereira-Leal, JoséRab proteins are small GTPases that act as essential regulators of vesicular trafficking. 44 subfamilies are known in humans, performing specific sets of functions at distinct subcellular localisations and tissues. Rab function is conserved even amongst distant orthologs. Hence, the annotation of Rabs yields functional predictions about the cell biology of trafficking. So far, annotating Rabs has been a laborio...