12 documents found, page 1 of 2
Microvascular Dysfunction Is Associated With Impaired Myocardial Work in Obstru...
Garcia Brás, P; Aguiar Rosa, S; Cardoso, I; Branco, L; Galrinho, A; Valentim Gonçalves, A; Thomas, B; Viegas, JM; Fiarresga, A; Branco, G; Pereira, RBackground Two-dimensional speckle tracking echocardiography has been shown to correlate with microvascular dysfunction, a hallmark of hypertrophic cardiomyopathy (HCM). We hypothesized that there is an association between myocardial work and left ventricular ischemia, with incremental value to global longitudinal strain, in patients with HCM. Methods and Results We performed a prospective assessment of patient...
Blunted Coronary Flow Velocity Reserve is Associated With Impairment in Systoli...
Aguiar Rosa, S; Rocha Lopes, L; Branco, L; Galrinho, A; Fiarresga, A; Thomas, B; Brás, P; Gonçalves, A; Cardoso, I; Papoila, A; Alves, M; Rio, PBackground Coronary microvascular dysfunction constitutes an important pathophysiological feature in hypertrophic cardiomyopathy (HCM). We aimed to assess the association between impaired coronary flow velocity reserve (CFVR) and ventricular systolic function and functional capacity. Methods Eighty-three patients with HCM were enrolled in this prospective cohort study. Patients underwent echocardiogram to evalu...
Proinflammatory Soluble CD40 Ligand Is Associated with the Systemic Extent of S...
Pereira da Silva, T; Napoleão, P; Pinheiro, T; Selas, M; Silva, F; Cruz Ferreira, R; Mota Carmo, MBackground and objectives: Polyvascular atherosclerosis is frequent and associated with a high cardiovascular risk, although the mechanisms regulating the atherosclerosis extent to single or multiple arterial territories are still poorly understood. Inflammation regulates atherogenesis and soluble CD40 ligand (sCD40L) is an inflammatory mediator associated with the presence of single-territorial atherosclerosis...
Does Permanent Atrial Fibrillation Modify Response to Cardiac Resynchronization...
Abreu, A; Oliveira, MM; Cunha, PS; Santa Clara, H; Portugal, G; Rodrigues, I; Santos, V; Almeida-Morais, L; Selas, M; Soares, R; Branco, LMINTRODUCTION: The benefits of cardiac resynchronization therapy (CRT) documented in heart failure (HF) may be influenced by atrial fibrillation (AF). We aimed to compare CRT response in patients in AF and in sinus rhythm (SR). METHODS: We prospectively studied 101 HF patients treated by CRT. Rates of clinical, echocardiographic and functional response, baseline NYHA class and variation, left ventricular ejectio...
Stratification of ST-Elevation Myocardial Infarction Patients Based on Soluble ...
Napoleão, P; Cabral, L; Selas, M; Freixo, C; Monteiro, MC; Criado, MB; Costa, M; Enguita, F; Viegas-Crespo, AM; Saldanha, C; Mota Carmo, MInvolvement of soluble CD40 ligand (sCD40L) in thrombosis and inflammation on the context of coronary artery disease is currently being revised. In that perspective, we had studied the association of sCD40L with markers of platelet activation and markers of endothelial and vascular function. On that cohort, a stratification of patients with acute myocardial infarction (AMI) 1 month after percutaneous coronary i...
Intracoronary Delivery of Human Mesenchymal/Stromal Stem Cells: Insights from C...
Fiarresga, A; Mata, M; Cavaco-Gonçalves, S; Selas, M; Simões, I; Oliveira, E; Carrapiço, B; Cardim, N; Cabral, J; Cruz Ferreira, R; Silva, CBACKGROUND: Mesenchymal stem/stromal cells have unique properties favorable to their use in clinical practice and have been studied for cardiac repair. However, these cells are larger than coronary microvessels and there is controversy about the risk of embolization and microinfarctions, which could jeopardize the safety and efficacy of intracoronary route for their delivery. The index of microcirculatory resis...
Percutaneous Treatment of Mitral Valve Regurgitation: Initial Experience with t...
Cacela, D; Fiarresga, A; Branco, LM; Galrinho, A; Rio, P; Selas, M; Cruz Ferreira, RINTRODUCTION: Mitral regurgitation (MR) is the most common valvular disease and has recently become the target of a number of percutaneous approaches. The MitraClip is virtually the only device for which there is considerable experience, with more than 20,000 procedures performed worldwide. OBJECTIVE: To describe our initial experience of the percutaneous treatment of MR with the MitraClip device. METHODS: We d...
Changes of Soluble CD40 Ligand in the Progression of Acute Myocardial Infarctio...
Napoleão, P; Monteiro, MC; Cabral, L; Criado, MB; Ramos, C; Selas, M; Viegas-Crespo, AM; Saldanha, C; Mota Carmo, M; Cruz Ferreira, R; Pinheiro, TReported in vitro data implicated soluble CD40 ligand (sCD40L) in endothelial dysfunction and angiogenesis. However, whether sCD40L could exert that influence in endothelial dysfunction and angiogenesis after injury in acute myocardial infarction (AMI) patients remains unclear. In the present study, we evaluated the association of sCD40L with markers of platelet activation, endothelial, and vascular function du...
Invasive Assessment of the Coronary Microcirculation Using the Index of Microci...
Fiarresga, A; Selas, M; Oliveira, E; Cavaco-Gonçalves, S; Cacela, D; Carrapiço, B; Cardim, N; Cruz Ferreira, RINTRODUCTION: The index of microcirculatory resistance (IMR) enables/provides quantitative, invasive, and real-time assessment of coronary microcirculation status. AIMS: The primary aim of this study was to validate the assessment of IMR in a large animal model, and the secondary aim was to compare two doses of intracoronary papaverine, 5 and 10 mg, for induction of maximal hyperemia and its evolution over time...
Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Interve...
Ramos, C; Napoleão, P; Selas, M; Freixo, C; Viegas Crespo, AM; Mota Carmo, M; Cruz Ferreira, R; Pinheiro, TWe examined the longitudinal changes of VEGF levels after percutaneous coronary intervention for predicting major adverse cardiac events (MACE) in coronary artery disease (CAD) patients. VEGF was measured in 94 CAD patients' serum before revascularization, 1-month and 1-year after. Independently of clinical presentation, patients had lower VEGF concentration than a cohort of healthy subjects (median, IQ: 15.9, ...