4 documents found, page 1 of 1
Reconstruction of cell-specific models capturing the influence of metabolism on...
Barata, Tânia; Pereira, Vítor; Neves, Ricardo Pires das; Rocha, MiguelThe imbalance of epigenetic regulatory mechanisms such as DNA methylation, which can promote aberrant gene expression profiles without affecting the DNA sequence, may cause the deregulation of signaling, regulatory, and metabolic processes, contributing to a cancerous phenotype. Since some metabolites are substrates and cofactors of epigenetic regulators, their availability can be affected by characteristic can...
Integration of stemness gene signatures reveals core functional modules of stem...
Barata, Tânia; Duarte, Isabel; Futschik, Matthias E.Stem cells encompass a variety of different cell types which converge on the dual capacity to self-renew and differentiate into one or more lineages. These characteristic features are key for the involvement of stem cells in crucial biological processes such as development and ageing. To decipher their underlying genetic substrate, it is important to identify so-called stemness genes that are common to differen...
Extracellular vesicles enriched with an endothelial cell pro-survival microRNA ...
Fernandes, Hugo; Zonnari, Alessandra; Abreu, Ricardo Cerqueira de; Aday, Sezin; Barão, Marta; Albino, Inês; Lino, Miguel; Branco, Ana; Seabra, CátiaEndothelial cell (EC) activity is essential for tissue regeneration in several (patho)physiological contexts. However, our capacity to deliver in vivo biomolecules capable of controlling EC fate is relatively limited. Here, we screened a library of microRNA (miR) mimics and identified 25 miRs capable of enhancing the survival of ECs exposed to ischemia-mimicking conditions. In vitro, we showed that miR-425-5p, ...
Reconstruction of tissue-specific genome-scale metabolic models for human cance...
Barata, Tânia; Vieira, Vítor; Rodrigues, Rúben André Costa; Neves, Ricardo Pires das; Rocha, MiguelCancer Stem Cells (CSCs) contribute to cancer aggressiveness, metastasis, chemo/radio-therapy resistance, and tumor recurrence. Recent studies emphasized the importance of metabolic reprogramming of CSCs for the maintenance and progression of the cancer phenotype through both the fulfillment of the energetic requirements and the supply of substrates fundamental for fast-cell growth, as well as through metabolit...