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Vital Pulp Therapy in Permanent Mature Posterior Teeth with Symptomatic Irrever...

Santos, João Miguel; Pereira, Joana F.; Marques, Andréa; Sequeira, Diana B.; Friedman, Shimon

Background and Objectives: Symptomatic irreversible pulpitis in permanent mature teeth is a common indication for nonsurgical root canal treatment (NSRCT), but contemporary studies have reported on vital pulp therapy (VPT) applied in such teeth as a less invasive treatment. This systematic review assessed the outcomes of VPT, including partial and full pulpotomy performed with hydraulic calcium silicate cements...


Subcutaneous Implantation Assessment of New Calcium-Silicate Based Sealer for W...

Santos, João Miguel; Coelho, Carolina M.; Sequeira, Diana B.; Marques, Joana A.; Pereira, Joana F.; Sousa, Vítor; Palma, Paulo J.; Santos, Ana C. G.

Calcium silicate-based sealers were recently introduced as a new class of endodontic sealers, with potential further benefits due to their bioactivity. The aim of this study was to evaluate the biocompatibility of two new hydraulic calcium silicate-based sealers, TotalFill BC Sealer (FKG, La Chaux-des-Fonds, Switzerland) and TotalFill BC Sealer HiFlow (FKG, La Chaux-des-Fonds, Switzerland) through subcutaneous ...


Tooth Discoloration after Regenerative Endodontic Procedures with Calcium Silic...

Palma, Paulo J.; Marques, Joana A.; Santos, Joana; Falacho, Rui I.; Sequeira, Diana B.; Diogo, Patrícia; Caramelo, Francisco; Ramos, João C.

The aim of the present ex vivo study was to assess and compare coronal discoloration induced by four endodontic biomaterials used in regenerative endodontic procedures (REPs). Root resection was executed horizontally, 2 mm apical to the cementoenamel junction, in all fifty-four teeth. After accessing the pulp chamber, specimens were randomly divided in groups and filled with either saline solution or blood, fol...


Does Apical Papilla Survive and Develop in Apical Periodontitis Presence after ...

Palma, Paulo J.; Martins, João; Diogo, Patrícia; Sequeira, Diana B.; Diogenes, Aníbal; Santos, João Miguel

Regenerative endodontic procedures (REPs) have emerged as a treatment option for immature necrotic teeth to allow the reestablishment of a newly formed vital tissue and enable continued root development. The apical papilla stem cells (SCAPs) play an important role in physiologic root development and may also contribute to further root development during REPs. The goal of these case reports is to show evidence o...


Effects of a New Bioceramic Material on Human Apical Papilla Cells

Sequeira, Diana B.; Seabra, Catarina M.; Palma, Paulo J.; Cardoso, Ana Luísa; Peça, João; Santos, João Miguel

Background: The development of materials with bioregenerative properties is critically important for vital pulp therapies and regenerative endodontic procedures. The aim of this study was to evaluate the cytocompatibility and cytotoxicity of a new endodontic biomaterial, PulpGuard, in comparison with two other biomaterials widely used in endodontic procedures, ProRoot Mineral Trioxide Aggregate (MTA) and Bioden...


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