16 documents found, page 1 of 2
Influence of Aldehyde Dehydrogenase Inhibition on Stemness of Endometrial Cance...
Serambeque, Beatriz; Mestre, Catarina; Barros, Gabriela; Marques Teixo, Ricardo Jorge; Marto, Carlos Miguel; Gonçalves, Ana CristinaPublisher Copyright: © 2024 by the authors.; Endometrial cancer is one of the most common gynaecological malignancies. Although often diagnosed at an early stage, there is a subset of patients with recurrent and metastatic disease for whom current treatments are not effective. Cancer stem cells (CSCs) play a pivotal role in triggering tumorigenesis, disease progression, recurrence, and metastasis, as high aldeh...
Short Peripheral Venous Catheters Contamination and the Dangers of Bloodstream ...
Osório, Nádia; Oliveira, Vânia; Costa, Maria Inês; Santos-Costa, Paulo; Serambeque, Beatriz; Gama, Fernando; Adriano, David; Graveto, JoãoPeripheral venous catheters (PVCs) are the most used vascular access devices in the world. However, failure rates remain considerably high, with complications such as PVC-related infections posing significant threats to patients' well-being. In Portugal, studies evaluating the contamination of these vascular medical devices and characterizing the associated microorganisms are scarce and lack insight into potent...
AZD-7648, a DNA-PK Inhibitor, Induces DNA Damage, Apoptosis, and Cell Cycle Arr...
Lapa, Beatriz Santos; Costa, Maria Inês; Figueiredo, Diana; Jorge, Joana; Alves, Raquel; Monteiro, Ana Raquel; Serambeque, Beatriz; Laranjo, MafaldaThe non-homologous end joining pathway is vital for repairing DNA double-strand breaks (DSB), with DNA-dependent protein kinase (DNA-PK) playing a critical role. Altered DNA damage response (DDR) in chronic (CML) and acute myeloid leukemia (AML) offers potential therapeutic opportunities. We studied the therapeutic potential of AZD-7648 (DNA-PK inhibitor) in CML and AML cell lines. This study used two CML (K-56...
Short peripheral venous catheters contamination and the dangers of bloodstream ...
Osório, Nádia; Oliveira, Vânia; Costa, Maria Inês; Santos-Costa, Paulo; Serambeque, Beatriz; Gama, Fernando; Adriano, David; Graveto, JoãoPeripheral venous catheters (PVCs) are the most used vascular access devices in the world. However, failure rates remain considerably high, with complications such as PVC-related infections posing significant threats to patients’ well-being. In Portugal, studies evaluating the contamination of these vascular medical devices and characterizing the associated microorganisms are scarce and lack insight into potent...
Localização subcelular do novo fotossensibilizador em células do melanoma ocula...
Guimarães, Tarcísio Guerra; Menezes Cardoso, Karla; Marto, Carlos Miguel; Teixo, Ricardo; Serambeque, Beatriz; Pereira, Nélson; Piñeiro, MartaIntrodução: O melanoma ocular é o objetivo de várias investigações em medicina e medicina veterinária devido à baixa taxa de resposta aos tratamentos conservadores convencionais1. A terapia fotodinâmica (PDT) é uma terapia mais conservadora para os tecidos não neoplásicos, que induz e ativa as vias de morte celular nos tecidos neoplásicos alvo2,3. O fotossensibilizador, luz e oxigenio são os três componentes vi...
Innovative Educational Approach in Healthcare-Associated Infection Prevention a...
Pinto, Maria do Rosário; Simões, Joaquim; Reis, Alcinda; Cunha, Fátima; Caseiro, Helena; Patrzała, Amelia; Bączyk, GrazinaPrevent and control healthcare-associated infections (HAIs) is a priority in healthcare assistance, not only due to present COVID-19 pandemic. Annually, around 3.2 million patients are affected by one of these infections and it is estimated that without controlling them, by 2050, 10 million more people could die every year, with especial relevance among elderly with infectious situations representing a third of...
Nursing Students’ Perceptions on Healthcare-Associated Infection Control and Pr...
Parreira, Pedro; Santos-Costa, Paulo; Pardal, João; Neves, Teresa; Bernardes, Rafael A.; Serambeque, Beatriz; Sousa, Liliana B.; Graveto, JoãoHealthcare-associated infections (HAI) are one of the major concerns worldwide, posing significant challenges to healthcare professionals’ education and training. This study intended to measure nursing students’ perceptions regarding their learning experiences on HAI prevention and control. In the first phase of the study, a cross-sectional and descriptive study with a convenience sample composed of undergradua...
Nursing Students' Perceptions on Healthcare-Associated Infection Control and Pr...
Parreira, Pedro; Santos-Costa, Paulo; Pardal, João; Neves, Teresa; Bernardes, Rafael A.; Serambeque, Beatriz; Sousa, Liliana B.; Graveto, JoãoHealthcare-associated infections (HAI) are one of the major concerns worldwide, posing significant challenges to healthcare professionals' education and training. This study intended to measure nursing students' perceptions regarding their learning experiences on HAI prevention and control. In the first phase of the study, a cross-sectional and descriptive study with a convenience sample composed of undergradua...
Applications of Photodynamic Therapy in Endometrial Diseases
Correia-Barros, Gabriela; Serambeque, Beatriz; Carvalho, Maria João; Marto, Carlos Miguel; Pineiro, Marta; Pinho e Melo, Teresa M. V. D.Photodynamic therapy (PDT) is a medical procedure useful for several benign conditions (such as wound healing and infections) and cancer. PDT is minimally invasive, presents few side effects, good scaring, and is able to minimal tissue destruction maintaining organ anatomy and function. Endoscopic access to the uterus puts PDT in the spotlight for endometrial disease treatment. This work systematically reviews ...
Ring-Fused meso-Tetraarylchlorins as Auspicious PDT Sensitizers: Synthesis, Str...
Laranjo, Mafalda; Pereira, Nelson A. M.; Oliveira, Andreia S. R.; Aguiar, Márcia Campos; Brites, Gonçalo Sousa; Nascimento, Bruno F. O.Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused meso-tetraarylchlorins, with different degrees of hydrophilicity (with methyl ester, hydroxymethyl, and carboxylic acid moieties), have been synthesized and their photophysical characterization as well as in vitro photocytotoxicity assessment against human melanoma and esophageal and bladder carcinomas was carried out. An integrated analysis of the photosens...