3 documents found, page 1 of 1
Urinary Cysteinyl Leukotrienes as Biomarkers of Endothelial Activation, Inflamm...
Reina-Couto, M; Santos-Oliveira, M; Pereira-Terra, P; Silva-Pereira, C; Quelhas-Santos, J; Duarte, Á; Martins, S; Serrão, P; Dias, CC; Morato, MCysteinyl leukotrienes (CysLT) are potent vascular leakage-promoting agents but have been scarcely explored in human septic shock (SS). We evaluated CysLT at admission and during hospitalization and their correlation with endothelial dysfunction, inflammation, oxidative stress, the renin–angiotensin–aldosterone system, and cardiac, renal, respiratory, and hepatic parameters in SS patients. Blood and spot-urine ...
Attenuation of the diffuse noxious inhibitory controls in chronic joint inflamm...
Pereira-Silva, R; Costa-Pereira, JT; Alonso, R; Serrão, P; Martins, I; Neto, FLThe noradrenergic system is paramount for controlling pain and emotions. We aimed at understanding the descending noradrenergic modulatory mechanisms in joint inflammatory pain and its correlation with the diffuse noxious inhibitory controls (DNICs) and with the onset of anxiodepressive behaviours. In the complete Freund’s adjuvant rat model of Monoarthritis, nociceptive behaviors, DNICs, and anxiodepressive-li...
Effect of Water Avoidance Stress on serum and urinary NGF levels in rats: diagn...
Dias, B; Serrão, P; Cruz, F; Charrua, ANerve growth factor (NGF) is thought to play a key role in chronic pain felt by bladder pain syndrome/interstitial cystitis (BPS/IC) patients by activating its high affinity receptor tropomyosin-related kinase subtype A (Trk A). Whether this pathway is also involved in the aggravation of pain sensation during stress events was here investigated. The levels of plasmatic NGF were increased in rats submitted to Wa...