3 documents found, page 1 of 1
Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catech...
Chavarria, Daniel; Benfeito, Sofia; Soares, Pedro; Lima, Carla; Garrido, Jorge; Serrão, Paula; Soares-da-Silva, Patrício; Remião, FernandoIncreased oxidative stress (OS) and depletion of nigrostriatal dopamine (DA) are closely linked to the neurodegeneration observed in Parkinson’s Disease (PD). Caffeic acid (CA)-based antioxidants were developed, and their inhibitory activities towards monoamine oxidases (MAOs) and catechol O-methyltransferases (COMT) were screened. The results showed that the incorporation of an extra double bond maintained or ...
Unexpected short- and long-term effects of chronic adolescent HU-210 exposure o...
Farinha Ferreira, Jorge Miguel; Rei, Nádia; Fonseca-Gomes, João; Miranda-Lourenço, Catarina; Serrão, Paula; Vaz, Sandra H.; Gomes, Joana I.Chronic adolescent cannabinoid receptor agonist exposure has been shown to lead to persistent increases in depressive-like behaviors. This has been a key obstacle to the development of cannabinoid-based therapeutics. However, most of the published work has been performed with only three compounds, namely Δ9-tetrahydrocannabinol, CP55,940 and WIN55,212-2. Hypothesizing that different compounds may lead to distin...
Impact of physical exercise on catechol-O-methyltransferase activity in depress...
Carneiro, Lara Sofia Rodrigues de Sousa Fernandes; Fonseca, António Manuel; Serrão, Paula; Vieira-Coelho, Maria Augusta; Mota, Maria Paula