23 documents found, page 1 of 3
Light-Activated Antimicrobial Surfaces Using Industrial Varnish Formulations to...
Santos, Madson R. E.; Mendonça, Patrícia V.; Branco, Rita; Sousa, Rúben; Dias, Carla; Serra, Arménio C.; Fernandes, José R.; Magalhães, Fernão D.Evidence has shown that hospital surfaces are one of the major vehicles of nosocomial infections caused by drug-resistant pathogens. Smart surface coatings presenting multiple antimicrobial activity mechanisms have emerged as an advanced approach to safely prevent this type of infection. In this work, industrial waterborne polyurethane varnish formulations containing for the first time cationic polymeric biocid...
Process Development for Flexible Films of Industrial Cellulose Pulp Using Super...
Ribeiro, Diana C. M.; Rebelo, Rafael C.; De Bon, Francesco; Coelho, Jorge F. J.; Serra, Arménio C.Due to environmental concerns, more attention has been given to the development of bio-based materials for substitution of fossil-based ones. Moreover, paper use is essential in daily routine and several applications of industrial pulp can be developed. In this study, transparent films were produced by industrial cellulose pulp solubilization in tetramethylguanidine based ionic liquids followed by its regenerat...
Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Prepara...
Ribeiro, Jessica; Mendonça, Patrícia V.; Coelho, Jorge; Matyjaszewski, Krzysztof; Serra, Arménio C.The cellular surface contains specific proteins, also known as lectins, that are carbohydrates receptors involved in different biological events, such as cell-cell adhesion, cell recognition and cell differentiation. The synthesis of well-defined polymers containing carbohydrate units, known as glycopolymers, by reversible deactivation radical polymerization (RDRP) methods allows the development of tailor-made ...
A Preliminary Evaluation of the Pro-Chondrogenic Potential of 3D-Bioprinted Pol...
Moxon, Samuel R.; Ferreira, Miguel J. S.; Santos, Patrícia dos; Popa, Bogdan; Gloria, Antonio; Katsarava, Ramaz; Tugushi, David; Serra, Arménio C.Degeneration of articular cartilage (AC) is a common healthcare issue that can result in significantly impaired function and mobility for affected patients. The avascular nature of the tissue strongly burdens its regenerative capacity contributing to the development of more serious conditions such as osteoarthritis. Recent advances in bioprinting have prompted the development of alternative tissue engineering t...
The Impact of the Addition of Compatibilizers on Poly (lactic acid) (PLA) Prope...
Gonçalves, F.A.M.M.; Cruz, Sandra M. A.; Coelho, Jorge F. J.; Serra, Arménio C.Poly (lactic acid) (PLA), due to its biodegradability, biocompatibility, and renewability, is one of the most promising biobased polymers for replacing some of the petrol-based materials. Low flexibility of PLA is overcome, by blending it with olefin-based polymers, such as polypropylene (PP). However, the use of compatibilizing agents is required to attain final materials with suitable mechanical properties. S...
Synthetic Calcium Phosphate Ceramics as a Potential Treatment for Bisphosphonat...
Paulo, Siri; Laranjo, Mafalda; Abrantes, Ana M.; Casalta-Lopes, João; Santos, Kathleen; Gonçalves, Ana C.; Paula, Anabela Baptista; Marto, Carlos Miguel(1) Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the most often seen side effects in patients treated with nitrogen-containing bisphosphonates (BPs), a post-surgical non-healing wound condition. Since calcium phosphate (CP) compounds are able to adsorb zoledronate (ZOL) when used as a drug delivery vehicle, we aimed to verify if these ceramics might have a potential protective e...
Platinum(II) Ring-Fused Chlorins as Near-Infrared Emitting Oxygen Sensors and P...
Pereira, Nelson A. M.; Laranjo, Mafalda; Casalta-Lopes, João; Serra, Arménio C.; Piñeiro, Marta; Pina, João; Seixas de Melo, J. SérgioNovel near-infrared luminescent compounds based on platinum(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins are described. These compounds have high photostability and display light emission, in particular simultaneous fluorescence and phosphorescence emission in solution at room temperature, in the biologically relevant 700-850 nm red and near-infrared (NIR) spectral region, making them excellent ...
Influence of feeding regimens on rat gut fluids and colonic metabolism of diclo...
Vieira, Amélia C. F.; Murdan, Sudaxshina; Serra, Arménio C.; Veiga, Francisco J.; Gonsalves, António M. d’A. Rocha; Basit, Abdul W.Feeding states may affect the performance of colonic prodrugs. The aim is to investigate the influence of feeding regimen in Wistar rats on: (i) distribution and pH contents along the gut and (ii) metabolism of two colonic prodrugs, diclofenac-β-cyclodextrin and a commercially available control, sulfasalazine, within the caecal and colonic contents. Male Wistar rats were subject to four different feeding regime...
3D printing of new biobased unsaturated polyesters by microstereo-thermal-litho...
Gonçalves, Filipa A. M. M.; Costa, Cátia S. M. F.; Fabela, Inês G. P.; Farinha, Dina; Faneca, Henrique; Simões, Pedro N.; Serra, Arménio C.New micro three-dimensional (3D) scaffolds using biobased unsaturated polyesters (UPs) were prepared by microstereo-thermal-lithography (μSTLG). This advanced processing technique offers indubitable advantages over traditional printing methods. The accuracy and roughness of the 3D structures were evaluated by scanning electron microscopy and infinite focus microscopy, revealing a suitable roughness for cell att...
2-Bromo-5-hydroxyphenylporphyrins for photodynamic therapy: photosensitization ...
Laranjo, Mafalda; Serra, Arménio C.; Abrantes, Margarida; Piñeiro, Marta; Gonçalves, Ana C.; Casalta-Lopes, João; Carvalho, LinaPhotodynamic therapy (PDT) is a therapeutic modality capable of inducing cell death by oxidative stress through activation of a sensitizer by light. Aryl-porphyrin with hydroxyl groups are good photosensitizers and presence of bromine atoms can enhance the photodynamic activity through heavy atom effect. These facts and our previous work made pertinent to compare the photodynamic capacity of tetraaryl brominate...