5 documents found, page 1 of 1
Relationship between the professional of reference and the permanence of ADHD p...
Guedes, Lucas Araujo; Vital, Wendel Coura; Magalhães, Christine Vianna Algarves; Serra, Carla Penido; Veloso, Vanja Maria
ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. S...
Lucas Filho, Milton Dayrell; Silva, Grazielle Caroline da; Côrtes, Steyner de França; Guia, Thiago Rennó dos Mares; Ferraz, Vany PerpetuaErythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC50=4.53±0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by sp...
Angiotensin-converting enzyme inhibition by Brazilian plants.
Braga, Fernão Castro; Serra, Carla Penido; Viana Júnior, Nilton de Souza; Oliveira, Alaíde Braga de; Côrtes, Steyner de França; Lombardi, Júlio AntônioThe potential antihypertensive activity of Brazilian plants was evaluated in vitro by its ability to inhibit the angiotensinconverting enzyme (ACE). Forty-four plants belonging to 30 families were investigated. Plants were selected based on their popular use as antihypertensive and/or diuretics. The following plants presented significant ACE inhibition rates: Calophyllum brasiliense, Combretum fruticosum, Leea ...
Validation of a colorimetric assay for the in vitro screening of inhibitors of ...
Serra, Carla Penido; Côrtes, Steyner de França; Lombardi, Júlio Antônio; Oliveira, Alaíde Braga de; Braga, Fernão CastroAnew method for the in vitro screening of plant extracts with potential angiotensin-converting enzyme (ACE) inhibitory activity is proposed. The method is based on the cleavage of the substrate hippuryl-glycyl-glycine by ACE and subsequent reaction with trinitrobenzenesulfonic acid to form 2,4,6-trinitrophenyl-glycyl-glycine, whose absorbance is determined at 415nm in a microtitre plate reader. Rabbit lung dehy...
Endothelium-dependent vasodilation induced by Hancornia speciosa in rat superio...
Ferreira, Herick Campos; Serra, Carla Penido; Endringer, Denise Coutinho; Lemos, Virgínia Soares; Braga, Fernão Castro; Côrtes, Steyner de FrançaThe vasodilator effect of the ethanolic extract of leaves from Hancornia speciosa Gomes (HSE) was evaluated in superior mesenteric artery rings. HSE produced a concentration-dependent vasodilation (IC50 ¼ 10.874.0 mg/mL) in arterial rings pre-contracted with phenylephrine, which was completely abolished in endothelium-denuded vessels. Endothelium-dependent vasodilation induced by HSE was strongly reduced by L-N...