4 documents found, page 1 of 1
Immunomodulatory and regenerative effects of the full and fractioned adipose ti...
Pinho, Andreia G.; Cibrão, Jorge R.; Lima, Rui; Gomes, Eduardo D.; Serra, Sofia C.; Lentilhas-Graça, José; Ribeiro, Clarisse; Lanceros-Méndez, S.Adipose tissue derived stem cells (ASCs) are recognized to secret a myriad of molecules (secretome) know to modulate inflammatory response, promote axonal growth as well vascular remodeling and cellular survival. In previous works we have reported the benefit effects of ASCs transplanted to the injury site in a rat model of spinal cord injury (SCI). Emerging evidence have shown that the therapeutic actions of t...
Crosstalk between glial and glioblastoma cells triggers the "go-or-grow" phenot...
Oliveira, Ana Isabel; Anjo, Sandra I.; Vieira de Castro, Joana; Serra, Sofia C.; Salgado, António J.; Manadas, Bruno; Costa, Bruno M.Background: Glioblastoma (GBM), the most malignant primary brain tumor, leads to poor and unpredictable clinical outcomes. Recent studies showed the tumor microenvironment has a critical role in regulating tumor growth by establishing a complex network of interactions with tumor cells. In this context, we investigated how GBM cells modulate resident glial cells, particularly their paracrine activity, and how th...
Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF
Martins, Luís F.; Costa, Rui O.; Pedro, Joana R.; Aguiar, Paulo; Serra, Sofia C.; Teixeira, Fabio G.; Sousa, Nuno; Salgado, António J.Mesenchymal stem cells (MSCs) have been used for cell-based therapies in regenerative medicine, with increasing importance in central and peripheral nervous system repair. However, MSCs grafting present disadvantages, such as, a high number of cells required for transplantation and low survival rate when transplanted into the central nervous system (CNS). In line with this, MSCs secretome which present on its c...
Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bio...
Teixeira, Fábio G.; Panchalingam, Krishna M.; Assunção-Silva, Rita; Serra, Sofia C.; Mendes-Pinheiro, Bárbara; Patrício, Patrícia; Jung, SunghoonIn recent years it has been shown that the therapeutic benefits of human mesenchymal stem/stromal cells (hMSCs) in the Central Nervous System (CNS) are mainly attributed to their secretome. The implementation of computer-controlled suspension bioreactors has shown to be a viable route for the expansion of these cells to large numbers. As hMSCs actively respond to their culture environment, there is the hypothes...