9 documents found, page 1 of 1
Matrix Metalloproteinase-9 levels are associated with brain lesion and persiste...
de Sousa, Diana Aguiar; Pereira Santos, Maria Conceição; Serra-Caetano, Ana; Lucas Neto, Lia; Sousa, Ana Luísa; Gabriel, Denis; Correia, ManuelBackground: Elucidating mechanisms of brain damage in cerebral venous thrombosis (CVT) would be instrumental to develop targeted therapies and improve prognosis prediction. Matrix metalloproteinase-9 (MMP-9), a gelatinase that degrades major components of the basal lamina, has been associated to blood-brain barrier disruption. We aimed to assess, in patients with CVT, the temporal change in serum concentrations...
Blood biomarkers associated with inflammation predict poor prognosis in cerebra...
de Sousa, Diana Aguiar; Pereira Santos, M. C.; Serra-Caetano, Ana; Lucas Neto, Lia; Sousa, A. L.; Gabriel, D.; Correia, M.; Gil-Gouveia, RaquelBackground and purpose: Experimental studies suggest inflammation can contribute to blood barrier disruption and brain injury in cerebral venous thrombosis (CVT). We aimed to determine whether blood biomarkers of inflammation were associated with the evolution of brain lesions, persistent venous occlusion or functional outcome in patients with CVT. Methods: Pathophysiology of Venous Infarction-Prediction of Inf...
Live Vaccine in Children with DiGeorge/22q11.2 Deletion Syndrome
Miranda, Mariana; Martins, Andreia Teixeira; Carvalho, Sara; Serra-Caetano, Ana; Esteves, Isabel; Gonçalo Marques, JoséIntroduction: Children with DiGeorge syndrome/chromosome 22q11.2 deletion syndrome might have a variable degree of immunodeficiency, which may limit the use of live vaccines. The aim of this study was to review the adverse effects of live vaccines and possible relation with immune status in patients with DiGeorge Syndrome/partial 22q11.2 deletion syndrome.Material and Methods: Retrospective study with analysis ...
Monozygotic twins concordant for common variable immunodeficiency : strikingly ...
Silva, Susana L.; Fonseca, Mariana; Pereira, Marcelo L. M.; Silva, Sara P.; Barbosa, Rita R.; Serra-Caetano, Ana; Blanco, Elena; Rosmaninho, PedroMonozygotic twins provide a unique opportunity to better understand complex genetic diseases and the relative contribution of heritable factors in shaping the immune system throughout life. Common Variable Immunodeficiency Disorders (CVID) are primary antibody defects displaying wide phenotypic and genetic heterogeneity, with monogenic transmission accounting for only a minority of the cases. Here, we report a ...
Vacinas vivas em crianças com síndrome de DiGeorge/Deleção 22q11.2
Miranda, Mariana; Martins, Andreia Teixeira; Carvalho, Sara; Serra-Caetano, Ana; Esteves, Isabel; Marques, José GonçaloChildren with DiGeorge syndrome/chromosome 22q11.2 deletion syndrome might have a variable degree of immunodeficiency, which may limit the use of live vaccines. The aim of this study was to review the adverse effects of live vaccines and possible relation with immune status in patients with DiGeorge Syndrome/partial 22q11.2 deletion syndrome.Material e Métodos: Foi realizado um estudo retrospetivo por revisão d...
Age-associated distribution of normal B-cell and plasma cell subsets in periphe...
Blanco, Elena; Pérez-Andrés, Martín; Arriba-Méndez, Sonia; Contreras-Sanfeliciano, Teresa; Criado, Ignacio; Pelak, Ondrej; Serra-Caetano, AnaBackground: Humoral immunocompetence develops stepwise throughout life and contributes to individual susceptibility to infection, immunodeficiency, autoimmunity, and neoplasia. Immunoglobulin heavy chain (IgH) isotype serum levels can partly explain such age-related differences, but their relationship with the IgH isotype distribution within memory B-cell (MBC) and plasma cell (PCs) compartments remains to be i...
Human naïve regulatory T-cells feature high steady-state turnover and are maint...
Silva, Susana L.; Albuquerque, Adriana S.; Serra-Caetano, Ana; Foxall, Russell B.; Pires, Ana R.; Matoso, Paula; Fernandes, Susana M.; Ferreira, JoãoNaïve FoxP3-expressing regulatory T-cells (Tregs) are essential to control immune responses via continuous replenishment of the activated-Treg pool with thymus-committed suppressor cells. The mechanisms underlying naïve-Treg maintenance throughout life in face of the age-associated thymic involution remain unclear. We found that in adults thymectomized early in infancy the naïve-Treg pool is remarkably well pre...
Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity...
Gomes, Ana Margarida; Soares, Maria Vieira; Ribeiro, Patrícia; Caldas, Joana; Póvoa, Vanda; Martins, Leila; Melão, Alice; Serra-Caetano, AnaAdult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring a better characterization of the molecular determinants underlying disease progression and resistance to treatment. Here, using a phospho-flow cytometry approach we show that adult diagnostic B-cell acute lymphoblastic leukemia specimens display PI3K/Akt pathway hyperactivation, irrespective of their BCR-ABL status and de...
Foxp3 induction in human and murine thymus precedes the CD4+ CD8+ stage but req...
Nunes-Cabaço, H.; C Ribot, Julie; Caramalho, Íris; Serra-Caetano, Ana; Silva-Santos, Bruno; E Sousa, AnaThe thymus generates a T-cell lineage dedicated to immune regulation, 'naturally occurring' regulatory T cells, best specified by the forkhead family transcription factor Foxp3. Here, we have conducted a parallel study in humans and mice where we have dissected the earliest stages of Foxp3 induction during thymocyte development. By analyzing a large collection of 21 human thymuses we show that Foxp3 can be cons...