2 documents found, page 1 of 1
Cerebrospinal fluid synaptic proteins as useful biomarkers in tyrosine hydroxyl...
Ortez, C.; Duarte, Ana Sofia; Ormazábal, A.; Serrano, M.; Pérez, A.; Pons, R.; Pineda, M.; Yapici, Z.; Fernández-Álvarez, E.; Domingo-Jiménez, R.Tyrosine hydroxylase (TH) deficiency is an inborn error of dopamine biosynthesis and a cause of early parkinsonism. Two clinical phenotypes have been described. Type "B": early onset severe encephalopathy; type "A": later onset, less severe and better response to L-dopa. We aimed to study the expression of several key dopaminergic and gabaergic synaptic proteins in the cerebrospinal fluid (CSF) of a series of p...
A Genomic Signature and the Identification of New Sporulation Genes
Abecasis, A. B.; Serrano, M.; Alves, R.; Quintais, L.; Pereira-Leal, J. B.; Henriques, A. O.Bacterial endospores are the most resistant cell type known to humans, as they are able to withstand extremes of temperature, pressure, chemical injury, and time. They are also of interest because the endospore is the infective particle in a variety of human and livestock diseases. Endosporulation is characterized by the morphogenesis of an endospore within a mother cell. Based on the genes known to be involved...