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Linkage disequilibrium and haplotype homozygosity in population samples genotyp...
Wang, Hui; Lin, Chia-Ho; Service, Susan; Chen, Yuguo; Freimer, Nelson; Sabatti, Chiara; Karayiorgou, Maria; Roos, J. Louw; Pretorious, HermanObjective: Analyze the information contained in homozygous haplotypes detected with high density genotyping. Methods: We analyze the genotypes of ∼2,500 markers on chr 22 in 12 population samples, each including 200 individuals. We develop a measure of disequilibrium based on haplotype homozygosity and an algorithm to identify genomic segments characterized by non-random homozygosity (NRH), taking into account ...
Data: 2006
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Origem: RepositóriUM - Universidade do Minho