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Therapy of chronic myeloid leukemia with imatinib mesylate in Brazil: a study o...
Funke,Vaneuza A. M.; Medeiro,Carlos R.; Lima,Denise H.; Setúbal,Daniela C.; Bitencourt,Marco A.; Bonfim,Carmem M.; Ruiz,Jefferson; Zanis Neto,JoséChronic Myeloid Leukemia (CML) is a clonal disease characterized by balanced translocation between chromosomes 9 and 22 (Philadelphia chromosome). The resulting BCR-ABL gene has tyrosine kinase activity which stimulates cellular growth. Imatinib mesylate is a potent and specific inhibitor of all ABL related kinases. Ninety-eight CML patients were treated with imatinib mesylate from October 2000 to January 2003....
Date: 2005
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Origin: Oasisbr