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Profile of cognitive impairment in late‐stage Parkinson's disease

Severiano e Sousa, Catarina; Fabbri, Margherita; Godinho, Catarina; Moiron Simões, Rita; Chendo, Inês; Coelho, Miguel; Martins, Isabel Pavão

Introduction: The profile of cognitive impairment associated with the late stages of Parkinson's disease (LSPD) is rarely reported. Its characterization is necessary to better understand the cognitive changes that occur as the disease progresses and to better contribute to its management. Methods: In this cross-sectional study, we characterized the cognitive profile of LSPD patients using the comprehensive asse...


Cognitive testing in late-stage Parkinson's disease: a critical appraisal of av...

Severiano e Sousa, Catarina; Alarcão, Joana; Martins, Isabel Pavão; Ferreira, Joaquim J

Objective: For patients with Parkinson's disease (PD), cognitive impairment is one of the most disabling non-motor symptoms, particularly in the late disease stages (LSPD). Without a common cognitive assessment battery, it is difficult to estimate its prevalence and limits comparisons across studies. In addition, some instruments traditionally used in PD may not be adequate for use in LSPD. We sought to identif...


Frequency of dementia in Parkinson's disease: a systematic review and meta-anal...

Severiano e Sousa, Catarina; Alarcão, Joana; Martins, Isabel Pavão; Ferreira, Joaquim J

Background: There is a considerable variation in the reported frequency of dementia in Parkinson's disease (PDD). The aim of this study was to evaluate the frequency of PDD reported in published studies and to examine the different methodological, clinical, and demographic factors that may contribute to this variation. Methods: We conducted a systematic review, searching EMBASE and MEDLINE databases for relevan...


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