11 documents found, page 1 of 2
Global gene expression profiling of oral cavity cancers suggests molecular hete...
Severino, Patricia; Alvares, Adriana M.; Michaluart, Pedro; Okamoto, Oswaldo K.; Nunes, Fabio D.; Moreira-Filho, Carlos A.; Tajara, Eloiza H.Made available in DSpace on 2022-04-29T08:44:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-01-01; Background: Oral squamous cell carcinoma (OSCC) is a frequent neoplasm, which is usually aggressive and has unpredictable biological behavior and unfavorable prognosis. The comprehension of the molecular basis of this variability should lead to the development of targeted therapies as well as to improve...
Lipid nanomaterials for targeted delivery of dermocosmetic ingredients: advance...
Souto, Eliana B.; Jäger, E.; Jäger, A.; tepánek, P.; Cano, A.; Viseras, C.; Barbosa, R. M.; Chorilli, M.; Zielinska, A.; Severino, P.; Naveros, B. C.Despite the health benefits of the sun, overexposure to solar radiation without proper precautions can cause irreversible damage to exposed skin. In the search for balance between the risks and benefits of exposure to solar radiation in human health, a technological alternative was found, the incorporation of photoprotective products in lipid nanoparticulate systems for topical application. These nanometric sys...
Physicochemical, pharmacokinetic and pharmacodynamic characterization of isradi...
Venkatesh, D. Nagasamy; Meyyanathan, S. N.; Shanmugam, R.; Kamatham, S. S.; Campos, J. R.; Dias-Ferreira, J.; Sanchez-Lopez, E.; Cardoso, J. C.Isradipine is a dihydropyridine calcium channel blocker (CCB) commonly used as vasodilator with antihypertensive properties. A remote-controlled release formulation for isradipine would substantially improve the clinical outcomes of the patients requiring chronic long-term treatment. In this work, sustained release tablets of isradipine, composed of hydroxypropylmethyl cellulose (HPMC), have been produced by we...
Development of a new formulation based on in situ photopolymerized polymer for ...
Novais, G. B.; Dos Santos, S.; Santana, R. J. R.; Filho, R. N. P.; Cunha, J. L. S.; Lima, B. S.; Araújo, A. A. S.; Severino, P.Spinal Cord Injury (SCI) promotes a cascade of inflammatory events that are responsible for neuronal death and glial scar formation at the site of the injury, hindering tissue neuroregeneration. Among the main approaches for the treatment of SCI, the use of biomaterials, especially gelatin methacryloyl (GelMA), has been proposed because it is biocompatible, has excellent mechanical properties, favoring cell adh...
Antibacterial activity of chitosan/collagen membranes containing red propolis e...
Loureiro, K. Cavalcante; Barbosa, T. Carvalho; Nery, M.; Chaud, M. Vinicius; Silva, C. Ferreira da; Andrade, L. Nalone; Corrêa, C. Bani; Jaguer, A.In this study we developed a mucoadhesive polymeric membrane wound dressing incorporating red propolis extract (HERP). Membranes were made using a casting method employing collagen, chitosan, polyethylene glycol (15, 20, and 30v%), and hydroethanolic extract of EtOH-H2O 70v% 30v% (v/v) of HERP (0.5, 1.0, and 1.5%). Membranes were extensively characterized to assess the thickness, pH, morphology using Scanning E...
Chapter 1 - Solid lipid nanoparticles (SLN): prediction of toxicity, metabolism...
Campos, J. R.; Severino, P.; Santini, A.; Silva, A. M.; Shegokar, Ranjita; Souto, S. B.; Souto, Eliana B.Various controlled delivery systems have been promoted in the recent decades in order to improve solubility, stability as well as bioavailability of poorly absorbed drugs. Solid lipidic nanoparticles (SLNs) are made of solid lipid matrix and a surfactant layer, and they have as characteristics the fact that can load poorly water-soluble drugs, delivering them at defined rates and thus enhancing their intracellu...
Cellular and molecular toxicology of nanoparticles
Zielinska, A.; Santos, D.; Campos, J. R.; Santini, A.; Severino, P.; Shimojo, A. A. M.; Souto, S. B.; Souto, Eliana B.This chapter discusses the most frequently used experimental models, both in vitro and in vivo, for the characterization of toxicological profile nanoparticles. It focuses on the description of the mechanisms involved in nanotoxicology, as well as the new trends in nanotoxicology lab analysis. The exponential use of nanomaterials in a range of applications in the biomedical field has fostered the need for an in...
Double membrane based on lidocaine-coated polymyxin-alginate nanoparticles for ...
Oliveira, D. M. L.; Rezende, P. S.; Barbosa, T. C.; Nalone, L. A.; Bani, C.; Tavares, D. S.; Silva, C. F. da; Chaud, M. V.; Padilha, F.; Cano, A.The aim of this study was to develop and characterize a double layer biomembrane for dual drug delivery to be used for the treatment of wounds. The membrane was composed of chitosan, hydroxypropyl methylcellulose and lidocaine chloride (anesthetic drug) in the first layer, and of sodium alginate-polymyxin B sulphate (antibiotic) nanoparticles as the second layer. A product with excellent thickness (0.01-0.02 mm...
d-α-tocopherol nanoemulsions: Size properties, rheological behavior, surface te...
Teixeira, M. C.; Severino, P.; Andreani, T.; Boonme, P.; Santini, A.; Silva, A. M.; Souto, E. B.The aim of this study was the assessment of the physicochemical stability of d-α-tocopherol formulated in medium chain triglyceride nanoemulsions, stabilized with Tween®80 and Lipoid®S75 as surfactant and co-surfactant, respectively. d-α-tocopherol was selected as active ingredient because of its well-recognized interesting anti-oxidant properties (such as radical scavenger) for food and pharmaceutical industri...
Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine ...
de Oliveira, G. G. G.; Feitosa, A.; Loureiro, K.; Fernandes, A. R.; Souto, E. B.; Severino, P.Paracetamol (PAR), phenylephrine hydrochloride (PHE) and chlorpheniramine maleate (CPM) are commonly used in clinical practice as antipyretic and analgesic drugs to ameliorate pain and fever in cold and flu conditions. The present work describes the use of thermal analysis for the characterization of the physicochemical compatibility between drugs and excipients during the development of solid dosage forms. The...