48 documents found, page 1 of 5
Correction: Diniz et al. Silver Nanoparticles-Composing Alginate/Gelatine Hydro...
Diniz, Flavia Resende; Maia, Romerito Cesar A. P.; de Andrade, Lucas Rannier M.; Andrade, Luciana Nalone; Vinicius Chaud, MarcoIn the original publication, there was a mistake in Figure 6 as published [...]
Lipid nanoparticles for the posterior eye segment
Bonilla, Lorena; Espina, Marta; Severino, Patricia; Cano, Amanda; Ettcheto, Miren; Camins, Antoni; García, Maria Luisa; Souto, Eliana B.This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior segment will be summarized. Moreover, preparation methods and different types and subtypes of lipid nanoparticles wil...
Uncaria tomentosa (Willd. ex Schult.): Focus on Nutraceutical Aspects
Nazhand, Amirhossein; Durazzo, Alessandra; Lucarini, Massimo; Silva, Amelia M.; Souto, Selma B.; Severino, Patricia; Souto, Eliana Maria BarbosaMedicinal plants have been globally exploiting as an alternative to chemical drugs in the treatment of several diseases due to low unwanted side effects, environmentally friendly nature, and low production costs. Therefore, it is important to analyze the therapeutic properties of various medicinal plants to understand their potential bioactivity. Uncaria tomentosa is one of these medicinal plants with many heal...
Global gene expression profiling of oral cavity cancers suggests molecular hete...
Severino, Patricia; Alvares, Adriana M.; Michaluart, Pedro; Okamoto, Oswaldo K.; Nunes, Fabio D.; Moreira-Filho, Carlos A.; Tajara, Eloiza H.Made available in DSpace on 2022-04-29T08:44:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-01-01; Background: Oral squamous cell carcinoma (OSCC) is a frequent neoplasm, which is usually aggressive and has unpredictable biological behavior and unfavorable prognosis. The comprehension of the molecular basis of this variability should lead to the development of targeted therapies as well as to improve...
Photoprotection and skin irritation effect of hydrogels containing hydroalcohol...
Batista, Cinthia M.; Queiroz, Luma A. de; Alves, Ângela V. F.; Reis, Elisiane C. A.; Santos, Fagne A.; Castro, Tailaine N.; Lima, Bruno S.The use of natural products in sunscreen formulations as a prophylactic measure against skin cancer is receiving special attention attributed to the photoprotective and antioxidant properties of their chemical components. In this work, we describe the development of topical hydrogel formulations containing hydroalcoholic extract of red propolis (HERP), and the evaluation of the dermal sensitizing effect of the ...
Encapsulation of Active Pharmaceutical Ingredients in Lipid Micro/Nanoparticles...
Favaro-Trindade, Carmen S.; Matos Junior, Fernando E. de; Okuro, Paula K.; Dias-Ferreira, João; Cano, Amanda; Severino, Patricia; Zielińska, AleksandraNanoencapsulation via spray cooling (also known as spray chilling and spray congealing) has been used with the aim to improve the functionality, solubility, and protection of drugs; as well as to reduce hygroscopicity; to modify taste and odor to enable oral administration; and many times to achieve a controlled release profile. It is a relatively simple technology, it does not require the use of low-cost solve...
Development of a Manometric Monitoring Method for Early Detection of Air Microb...
dos Santos-Neto, Agenor G.; Pinheiro, Malone S.; dos Santos, Monica C.; Alves, Lumar L.; Poderoso, Renata R. S.; Cardoso, Juliana C.; Severino, PatriciaAtmospheric air is a microbial habitat of pathogenic bioaerosols that may pose serious risks to humans. A commonly laboratory-based approach for the diagnosis of such infections in the bloodstream is the blood culture analysis. Its clinical relevance is attributed to the fact that these infections are characterized by high rates of morbidity and mortality, requiring the need for efficient methods for rapid diag...
Biosurfactants: Properties and Applications in Drug Delivery, Biotechnology and...
Bjerk, Thiago R; Severino, Patricia; Jain, Sona; Marques, Conrado; Silva, Amélia M.; Pashirova, Tatiana; Souto, Eliana B.Surfactants are amphiphilic compounds having hydrophilic and hydrophobic moieties in their structure. They can be of synthetic or of microbial origin, obtained respectively from chemical synthesis or from microorganisms' activity. A new generation of ecofriendly surfactant molecules or biobased surfactants is increasingly growing, attributed to their versatility of applications. Surfactants can be used as drug ...
Applied nanotechnologies in anticoagulant therapy: from anticoagulants to coagu...
Patriota, Yuri B. G.; Chaves, Luíse L.; Gocke, Evren H.; Severino, Patricia; Soares, Mônica F. R.; Soares-Sobrinho, José L.; Souto, Eliana B.Heparin-based delivery systems have been explored to improve their therapeutic efficacy and to reduce toxicity for different administration routes. Regardless of the applied drug delivery system (DDS), the evaluation of anticoagulant performance is instrumental for the development of a suitable DDS. The understanding of the range of anticoagulant assays, together with their key applications and limitations, is ...
Biosurfactants: properties and applications in drug delivery, biotechnology and...
Bjerk, Thiago R.; Severino, Patricia; Jain, Sona; Marques, Conrado; Silva, Amélia M.; Pashirova, Tatiana; Souto, Eliana B.Surfactants are amphiphilic compounds having hydrophilic and hydrophobic moieties in their structure. They can be of synthetic or of microbial origin, obtained respectively from chemical synthesis or from microorganisms activity. A new generation of ecofriendly surfactant molecules or biobased surfactants is increasingly growing, attributed to their versatility of applications. Surfactants can be used as drug d...