11 documents found, page 1 of 2
HBM4EU chromates study: the Portuguese integrated and harmonized study on expos...
Viegas, Susana; Martins, Carla; Ribeiro, Edna; Ladeira, Carina; Pinhal, Hermínia; Nogueira, Ana; Santos, Sílvia; Tavares, Ana; Gomes, Bruno CostaIn the scope of the European Union (EU) human biomonitoring initiative, a multicentric study on different occupational settings from several European countries was performed, to provide information on occupational exposure to hexavalent chromium [Cr(VI)], a known lung carcinogen. Biomonitoring approaches were used to obtain exposure data to support the implementation of new risk management measures and policy a...
Aplicação da biomonitorização humana para avaliação da exposição ocupacional a ...
Louro, Henriqueta; Gomes, Bruno Costa; Saber, Anne Thoustrup; Iamiceli, Anna Laura; Göen, Thomas; Jones, Kate; Katsonouri, AndromachiOs hidrocarbonetos aromáticos policíclicos (HAPs) são produtos químicos com impacto em saúde ocupacional, pelo que a avaliação da exposição humana através de estudos de biomonitorização tem aumentado nos últimos anos. No entanto, os dados obtidos são ainda insuficientes para os reguladores e decisores políticos. Este trabalho, no contexto da Iniciativa Europeia em Biomonitorização Humana (HBM4EU), descreve uma ...
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europ...
Louro, Henriqueta; Gomes, Bruno Costa; Saber, Anne Thoustrup; Iamiceli, Anna Laura; Göen, Thomas; Jones, Kate; Katsonouri, AndromachiPolycyclic aromatic hydrocarbons (PAHs) are among the chemicals with proven impact on workers’ health. The use of human biomonitoring (HBM) to assess occupational exposure to PAHs has become more common in recent years, but the data generated need an overall view to make them more usable by regulators and policymakers. This comprehensive review, developed under the Human Biomonitoring for Europe (HBM4EU) Initia...
Using human biomonitoring for the risk assessment of polycyclic aromatic hydroc...
Viegas, Susana; Gomes, Bruno Costa; Louro, Henriqueta; Silva, Maria João; Joksić, Agnes Šömen; Kirinčič, Stanislava; Mahiout, Selma; Santonen, TiinaBackground and Purpose: The Human Biomonitoring Initiative (HBM4EU) is a joint effort of 28 countries, the European Environment Agency and the European Commission, co-funded under Horizon 2020. HBM4EU is generating evidence of the current exposure of European citizens to chemicals and the possible health effects in order to assess the associated risks and support policy making towards human health protection. P...
Thyroid cancer: the quest for genetic susceptibility involving DNA repair genes
Santos, Luís S.; Gomes, Bruno Costa; Bastos, Hélder N.; Gil, Octávia M.; Azevedo, Ana Paula; Ferreira, Teresa C.; Limbert, Edward; Silva, Susana N.The incidence of thyroid cancer (TC), particularly well-differentiated forms (DTC), has been rising and remains the highest among endocrine malignancies. Although ionizing radiation (IR) is well established on DTC aetiology, other environmental and genetic factors may also be involved. DNA repair single nucleotide polymorphisms (SNPs) could be among the former, helping in explaining the high incidence. To furth...
Occupational exposure to hexavalent chromium: biomarkers of genotoxicity in hum...
Afonso, Catarina; Gomes, Bruno Costa; Louro, Henriqueta; Nogueira, Ana; Pinhal, Hermínia; Reis, Susana; Ventura, Célia; Ladeira, Carina; Ribeiro, EdnaThe hexavalent chromium [Cr(VI)] is a human carcinogen, which is still authorized for use in several industrial settings because it has been difficult to replace. This was the reasoning to select it as a priority chemical by the European Human Biomonitoring Initiative (HBM4EU, https://www.hbm4eu.eu/), which aims to bridge chemicals human exposure to their possible impact on health. For that purpose, not only ex...
Occupational exposure to Hexavalent chromium: the portuguese case within the co...
Afonso, Catarina; Gomes, Bruno Costa; Louro, Henriqueta; Ladeira, Carina; Pinhal, Hermínia; Nogueira, Ana; Santos, Sílvia; Ventura, Célia; Ribeiro, EdnaBackground: The EU human biomonitoring initiative (HBM4EU) aims to coordinate and advance human biomonitoring across Europe. A multicenter study intending to characterize occupational exposure to hexavalent chromium [Cr(VI)], a human carcinogen, was setup in several industrial settings across Europe. In Portugal, the study was developed in one aircraft maintenance company since the substitution of Cr(VI) in thi...
The Usefulness of Early Effect Biomarkers in Monitoring Occupational Exposure t...
Afonso, Catarina; Gomes, Bruno Costa; Louro, Henriqueta; Nogueira, Ana; Pinhal, Hermínia; Reis, S.; Ventura, Célia; Ladeira, Carina; Ribeiro, EdnaIntroduction: In the frame of the Project HBM4EU (https://www.hbm4eu.eu/) a biomonitoring study is being conducted across Europe to characterize occupational exposure to hexavalent chromium [Cr(VI)], a recognized human lung carcinogen. Herein we present the results of biomarkers of exposure and effect characterized in a group of workers from a Portuguese aircraft maintenance company, where Cr(VI) replacement is...
A case study on occupational exposure to Chromium (VI), Nickel, PAH mixtures an...
Silva, Maria João; Louro, Henriqueta; Viegas, Susana; Gomes, Bruno Costa; Santonen, Tiina; Kortenkamp, Andreas; Lebret, ErikBackground: In several industries, e.g., aircrafts maintenance, workers are co-exposed to a range of hazardous substances, including hexavalent chromium [Cr (VI)], nickel (Ni) and polycyclic aromatic hydrocarbons (PAHs). Each of these compounds can cause serious health effects, including lung cancer. However, the association between exposure and health outcome has not been analysed from a mixture perspective, i...
The use of effect biomarkers in human biomonitoring studies: exposure to hexava...
Gomes, Bruno Costa; Louro, Henriqueta; Huuskonen, Pasi; Santonen, Tiina; Huumonen, Katriina; Ndaw, Sophie; Fernández, Mariana F.; Silva, Maria JoãoHexavalent chromium, Cr(VI) is a human carcinogen (Group 1, IARC), and its expo-sure has been associated with increased lung cancer risk, particularly in exposed workers. The general population may be exposed to Cr(VI) through food, drinking water and tobacco smoke. Under the Human Biomonitoring for Europe Initiative (HBM4EU), Cr(VI) has been considered a priority substance, indicating the need for generating a...