6 documents found, page 1 of 1
Nano-armed Limosilactobacillus reuteri for enhanced photo-immunotherapy and mic...
Xu, Haiting; Wang, Yajun; Liu, Ga; Zhu, Zhenhua; Shahbazi, Mohammad-Ali; Reis, R. L.; Kundu, Subhas C; Shi, Xiaoxiao; Zu, Menghang; Xiao, BoDespite being a groundbreaking approach to treating colorectal cancer (CRC), the efficacy of immunotherapy is significantly compromised by the immunosuppressive tumor microenvironment and dysbiotic intestinal microbiota. Here, leveraging the superior carrying capacity and innate immunity-stimulating property of living bacteria, a nanomedicine-engineered bacterium, LR-S-CD/CpG@LNP, with optical responsiveness, i...
An oral nanomedicine elicits in situ vaccination effect against colorectal cancer
Zu, Menghang; Ma, Ya; Zhang, Jun; Sun, Jianfeng; Shahbazi, Mohammad-Ali; Pan, Guoqing; Reis, R. L.; Kundu, Subhas C; Liu, Jinyao; Xiao, BoOral administration is the most preferred approach for treating colon diseases, and in situ vaccination has emerged as a promising cancer therapeutic strategy. However, the lack of effective drug delivery platforms hampered the application of in situ vaccination strategy in oral treatment of colorectal cancer (CRC). Here, we construct an oral coreâ shell nanomedicine by preparing a silk fibroin-based dual s...
Transient mild photothermia improves therapeutic performance of oral nanomedici...
Ma, Ya; Gou, Shuangquan; Zhu, Zhenhua; Sun, Jianfeng; Shahbazi, Mohammad-Ali; Si,Tieyan; Xu, Cheng; Ru, Jinlong; Shi, Xiaoxiao; Reis, R. L.The treatment outcomes of oral medications against ulcerative colitis (UC) have long been restricted by low drug accumulation in the colitis mucosa and subsequent unsatisfactory therapeutic efficacy. Here, high-performance pluronic F127 (P127)-modified gold shell (AuS)-polymeric core nanotherapeutics loading with curcumin (CUR) is constructed. Under near-infrared irradiation, the resultant P127-AuS@CURs generat...
Extracellular vesicles from nanomedicine-trained intestinal microbiota substitu...
Zu, Menghang; Liu, Ga; Xu, Haiting; Zhu, Zhenhua; Zhen, Junfeng; Shi, Baoyi; Shahbazi, Mohammad-Ali; Reis, R. L.; Kundu, Subhas C; Nie, GuangjunThe biosafety concerns associated with fecal microbiota transplant (FMT) limit their clinical application in treating ulcerative colitis (UC). Gut microbiota secrete abundant extracellular vesicles (Gm-EVs), which play a critical role in bacteria-to-bacteria and bacteria-to-host communications. Herein, intestinal microbiota are trained using tea leaf lipid/pluronic F127-coated curcumin nanocrystals (CN@Lp127s),...
Dual-driven nanomotors enable tumour penetration and hypoxia alleviation for ca...
Wu, Jiaxue; Yi, Shixiong; Cao, Yingui; Zu, Menghang; Li, Baoyi; Yang, Wenjing; Shahbazi, Mohammad-Ali; Wan, Ying; Reis, R. L.; Kundu, Subhas CThe treatment efficacies of conventional medications against colorectal cancer (CRC) are restricted by a low penetrative, hypoxic, and immunosuppressive tumor microenvironment. To address these restrictions, we developed an innovative antitumor platform that employs calcium overload-phototherapy using mitochondrial N770-conjugated mesoporous silica nanoparticles loaded with CaO2 (CaO2–N770@MSNs). A loading leve...
Bioinspired polyacrylic acid-based dressing: wet adhesive, self-healing, and mu...
Wang, Lingshuang; Duan, Lian; Liu, Ga; Sun, Jianfeng; Shahbazi, Mohammad-Ali; Kundu, Subhas C; Reis, R. L.; Xiao, Bo; Yang, XiaoPolyacrylic acid (PAA) and its derivatives are commonly used as essential matrices in wound dressings, but their weak wet adhesion restricts the clinical application. To address this issue, a PAA-based coacervate hydrogel with strong wet adhesion capability is fabricated through a facile mixture of PAA copolymers with isoprenyl oxy poly(ethylene glycol) ether and tannic acid (TA). The poly(ethylene glycol) segm...