Introduction. Antimicrobial resistance is a major public health threat. Antimicrobial stewardship (AMS) is one of the key strategies to overcome resistance, but robust evidence on the effect of specific interventions is lacking. We report an interrupted time series (ITS) analysis of a persuasive AMS intervention implemented during a KPC producing Klebsiella pneumoniae outbreak. Methods. A controlled ITS for car...
A challenging problem in a linear regression model is to select a parsimonious model which is robust to the presence of contamination in the data. In this paper, we present a sparse linear approach which detects outliers by using a highly robust regression method. The model with optimal predictive ability as measured by the median absolute deviation of the prediction errors on JackKnife subsets is used to detec...