65 documents found, page 1 of 7
Natural products-based antiangiogenic agents: new frontiers in cancer therapy
Azevedo, T; Ferreira, T; Pena-Corona, SI; Cortes, H; Silva-Reis, R; Gil da Costa, RM; Faustino-Rocha, Ana I; Oliveira, PA; Calina, D; Cardoso, MAngiogenesis, vital for tumor growth and metastasis, is a promising target in cancer therapy. Natural compounds offer potential as antiangiogenic agents with reduced toxicity. This review provides a comprehensive overview of natural product-based antiangiogenic therapies, focusing on molecular mechanisms and therapeutic potential. A systematic search identified relevant articles from 2019 to 2023. Various natur...
Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: E...
Taheri, Y; Sharifi-Rad, J; Antika, G; Yilmaz, YB; Tumer, TB; Abuhamdah, S; Chandra, S; Saklani, S; Kiliç, CS; Sestito, S; Dastan, SD; Kumar, MLuteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing to their biological and pharmacological value. Many preclinical studies report that luteolin present excellent antioxidant, anticancer, antimicrobial, neuroprotective, cardioprotective, a...
Nanotechnology-Based Strategies for Berberine Delivery System in Cancer Treatme...
Iqbal, MJ; Quispe, C; Javed, Z; Sadia, H; Qadri, QR; Raza, S; Salehi, B; Martins, N; Abdulwanis Mohamed, Z; Sani Jaafaru, M; Abdull Razis, AFCancer is a multifactorial disease characterized by complex molecular landscape and altered cell pathways that results in an abnormal cell growth. Natural compounds are target-specific and pose a limited cytotoxicity; therefore, can aid in the development of new therapeutic interventions for the treatment of this versatile disease. Berberine is a member of the protoberberine alkaloids family, mainly present in ...
Green Synthesized Silver Nanoparticles as Potent Antifungal Agent against Asper...
Anum, F; Jabeen, K; Javad, S; Iqbal, S; Tahir, A; Javed, Z; Martins, N; Ayatollahi, SA; Sharifi-Rad, J; Alshehri, MM; Cho, WCMedicinal plants are composed of a rich pool of biomolecules and have been increasingly recognized for their antimicrobial properties; however, increasing concerns have been put on the bioavailability features. Thus, this study is aimed at exploring the synthesis and characterization of silver nanoparticles synthesized by Chenopodium album L. leaf extract and assessing the antifungal activity against Aspergillu...
Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus
Ramírez-Alarcón, K; Victoriano, M; Mardones, L; Villagran, M; Al-Harrasi, A; Al-Rawahi, A; Martins, N; Sharifi-Rad, J; Martorell, MType 2 diabetes Mellitus (T2DM) prevalence has significantly increased worldwide in recent years due to population age, obesity, and modern sedentary lifestyles. The projections estimate that 439 million people will be diabetic in 2030. T2DM is characterized by an impaired ß-pancreatic cell function and insulin secretion, hyperglycemia and insulin resistance, and recently the epigenetic regulation of ß-pancreat...
Phytosterols: From Preclinical Evidence to Potential Clinical Applications
Salehi, B; Quispe, C; Sharifi-Rad, J; Martins, N; Nigam, M; Mishra, AP; Konovalov, DA; Orobinskaya, V; Abu-Reidah, IM; Zam, W; Sharopov, F; Venneri, TPhytosterols (PSs) are plant-originated steroids. Over 250 PSs have been isolated, and each plant species contains a characteristic phytosterol composition. A wide number of studies have reported remarkable pharmacological effects of PSs, acting as chemopreventive, anti-inflammatory, antioxidant, antidiabetic, and antiatherosclerotic agents. However, PS bioavailability is a key issue, as it can be influenced by...
Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Mole...
Sharifi-Rad, J; Martins, N; López-Jornet, P; Lopez, EPF; Harun, N; Yeskaliyeva, B; Beyatli, A; Sytar, O; Shaheen, S; Sharopov, F; Taheri, Y; Docea, AOCoumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti-inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase-2 (CK2) inhibitory, antifungal, antiviral, Alzheimer's disease inhibition, neuroprotective, anticonvulsant, phytoalexins, ulcerogenic, and antihypertensi...
Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy
Sharifi-Rad, J; Quispe, C; Patra, JK; Singh, YD; Panda, MK; Das, G; Adetunji, CO; Michael, OS; Sytar, O; Polito, L; Živkovic, J; Martins, NPaclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a representative of a class of diterpene taxanes, which are nowadays used as the most common chemotherapeutic agent against many forms of cancer. It possesses scientifically proven anticancer activity against, e.g., ovarian, lung, and brea...
Bioactive Compounds as Potential Agents for Sexually Transmitted Diseases Manag...
Sharifi-Rad, J; Quispe, C; Rahavian, A; Pereira Carneiro, JN; Rocha, JE; Alves Borges Leal, AL; Bezerra Morais Braga, MF; Melo Coutinho, HDSexually transmitted diseases (STDs) are produced by pathogens like bacteria, fungi, parasites, and viruses, and may generate severe health problems such as cancer, ulcers, and even problems in the newborn. This narrative review aims to present updated information about the use of natural bioactive compounds for the prevention and treatment of sexually transmitted infections. A search of the literature was perf...
Quercetin Impact in Pancreatic Cancer: An Overview on Its Therapeutic Effects
Asgharian, P; Tazehkand, AP; Soofiyani, SR; Hosseini, K; Martorell, M; Tarhriz, V; Ahangari, H; Martins, N; Sharifi-Rad, J; Almarhoon, ZM; Ydyrys, APancreatic cancer (PC) is a lethal malignancy cancer, and its mortality rates have been increasing worldwide. Diagnosis of this cancer is complicated, as it does not often present symptoms, and most patients present an irremediable tumor having a 5-year survival rate after diagnosis. Regarding treatment, many concerns have also been raised, as most tumors are found at advanced stages. At present, anticancer com...