17 documents found, page 1 of 2
Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health
Salehi, B; Machin, L; Monzote, L; Sharifi-Rad, J; Ezzat, SM; Salem, MA; Merghany, RM; El Mahdy, NM; Klllç, CS; Sytar, O; Sharifi-Rad, M; Sharopov, FQuercetin (Que) and its derivatives are naturally occurring phytochemicals with promising bioactive effects. The antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti-Alzheimer's, antiarthritic, cardiovascular, and wound-healing effects of Que have been extensively investigated, as well as its anticancer activity against different cancer cell lines has been recently reported. Que and its derivatives...
Diet, lifestyle and cardiovascular diseases: Linking pathophysiology to cardiop...
Sharifi-Rad, J; Rodrigues, CF; Sharopov, F; Docea, AO; Karaca, AC; Sharifi-Rad, M; Karincaoglu, DK; Gülseren, G; Senol, E; Demircan, E; Taheri, YHeart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumpti...
Plant-derived bioactives and oxidative stress-related disorders: A key trend to...
Salehi, B; Azzini, E; Zucca, P; Varoni, EM; Kumar, NVA; Dini, L; Panzarini, E; Rajkovic, J; Fokou, PVT; Peluso, I; Mishra, AP; Nigam, M; Rayess, YEPlants and their corresponding botanical preparations have been used for centuries due to their remarkable potential in both the treatment and prevention of oxidative stress-related disorders. Aging and aging-related diseases, like cardiovascular disease, cancer, diabetes, and neurodegenerative disorders, which have increased exponentially, are intrinsically related with redox imbalance and oxidative stress. Hu...
Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysi...
Sharifi-Rad, M; Anil Kumar, NV; Zucca, P; Varoni, EM; Dini, L; Panzarini, E; Rajkovic, J; Tsouh Fokou, PV; Azzini, E; Peluso, I; Prakash Mishra, AOxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects at a mitochondrial DNA level, as well as functional alteration of several enzymes and cellular structures leading to aberrations in gene expression. The modern...
Impact of natural compounds on neurodegenerative disorders: From preclinical to...
Sharifi-Rad, M; Lankatillake, C; Dias, DA; Docea, AO; Mahomoodally, MF; Lobine, D; Chazot, PL; Kurt, B; Tumer, TB; Moreira, AC; Sharopov, FAmong the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their...
Understanding Camellia sinensis using Omics technologies along with endophytic ...
Tshikhudo, P; Ntushelo, K; Mudau, F; Salehi, B; Sharifi-Rad, M; Martins, N; Martorell, M; Sharifi-Rad, JCamellia sinensis is the most consumed beverage worldwide. It contains a wide variety of secondary metabolites, such as alkaloids, saponins, tannins, catechins, and polyphenols, generated through a condensation reaction of cinnamic acid with three malonyl-CoA groups. In addition to the metabolic processes occurring within this plant, there are also some plant-associated bacterial endophytes. These bacteria resi...
The therapeutic potential of naringenin: A review of clinical trials
Salehi, B; Fokou, P; Sharifi-Rad, M; Zucca, P; Pezzani, R; Martins, N; Sharifi-Rad, JNaringenin is a flavonoid belonging to flavanones subclass. It is widely distributed in several Citrus fruits, bergamot, tomatoes and other fruits, being also found in its glycosides form (mainly naringin). Several biological activities have been ascribed to this phytochemical, among them antioxidant, antitumor, antiviral, antibacterial, anti-inflammatory, antiadipogenic and cardioprotective effects. Nonetheles...
The therapeutic potential of Apigenin
Salehi, B; Venditti, A; Sharifi-Rad, M; Kregiel, D; Sharifi-Rad, J; Durazzo, A; Lucarini, M; Santini, A; Souto, EB; Novellino, E; Antolak, H; Azzini, ESeveral plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo ...
Epibatidine: A promising natural alkaloid in health
Salehi, B; Sestito, S; Rapposelli, S; Peron, G; Calina, D; Sharifi-Rad, M; Sharopov, F; Martins, N; Sharifi-Rad, JEpibatidine is a natural alkaloid that acts at nicotinic acetylcholine receptors (nAChRs). The present review aims to carefully discuss the affinity of epibatidine and its synthetic derivatives, analogues to nAChRs for a4ß2 subtype, pharmacokinetic parameters, and its role in health. Published literature shows a low affinity and lack of binding of epibatidine and its synthetic analogues to plasma proteins, indi...
Plant-derived bioactives in oral mucosal lesions: A key emphasis to Curcumin, L...
Salehi, B; Jornet, PL; López, EPF; Calina, D; Sharifi-Rad, M; Ramírez-Alarcón, K; Forman, K; Fernández, M; Martorell, M; Setzer, WN; Martins, NOral mucosal lesions have many etiologies, including viral or bacterial infections, local trauma or irritation, systemic disorders, and even excessive alcohol and tobacco consumption. Folk knowledge on medicinal plants and phytochemicals in the treatment of oral mucosal lesions has gained special attention among the scientific community. Thus, this review aims to provide a brief overview on the traditional know...