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Coma in adult cerebral venous thrombosis: the BEAST study

Ranjan, Redoy; Ken‐Dror, Gie; Martinelli, Ida; Grandone, Elvira; Hiltunen, Sini; Lindgren, Erik; Margaglione, Maurizio; Duchez, Veronique Le Cam

Background and purpose: Coma is an independent predictor of poor clinical outcomes in cerebral venous thrombosis (CVT). We aimed to describe the association of age, sex, and radiological characteristics of adult coma patients with CVT. Methods: We used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positive...


An Open Source Framework Approach to Support Condition Monitoring and Maintenance

Campos, Jaime; Sharma, Pankaj; Albano, Michele; Ferreira, Luís Lino; Larrañaga, Martin

This paper discusses the integration of emergent ICTs, such as the Internet of Things (IoT), the Arrowhead Framework, and the best practices from the area of condition monitoring and maintenance. These technologies are applied, for instance, for roller element bearing fault diagnostics and analysis by simulating faults. The authors first undertook the leading industry standards for condition-based maintenance (...


Genetic and lifestyle risk factors for MRI-defined brain infarcts in a populati...

Chauhan, Ganesh; Adams, Hieab H.H.; Satizabal, Claudia L.; Bis, Joshua C.; Teumer, Alexander; Sargurupremraj, Muralidharan; Hofer, Edith

Objective: To explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts. Methods: We performed meta-analyses of genome-wide association studies (GWAS) and examined associations of vascular risk factors and their genetic risk scores (GRS) with MRI-defined BI and a subset of BI, namely, small subcortical BI (SSBI), in 18 population-based cohorts (n = 20,949) f...


An iterative process to extract value from maintenance projects

Mejía Niño, Carolina; Albano, Michele; Jantunen, Erkki; Sharma, Pankaj; Campos, Jaime; Baglee, David

Research and development projects are producing novel maintenance strategies and techniques. Anyway, it is not straightforward to transfer results from the lab to the real world, and thus many projects, both internal to a company and in cooperation between the members of a consortium, speculate how to perform this feat, called “exploitation” in the context of European projects. This paper discusses the necessit...


Energy Saving by Blockchaining Maintenance

Albano, Michele; Sharma, Pankaj; Campos, Jaime; Jantunen, Erkki

The development and interest in Industry 4.0 together with rapid development of Cyber Physical Systems has created magnificent opportunities to develop maintenance to a totally new level. The Maintenance 4.0 vision considers massive exploitation of information regarding factories and machines to improve maintenance efficiency and efficacy, for example by facilitating logistics of spare parts, but on the other h...


Blockchain Technology Helps Maintenance to Stop Climate Change

Albano, Albano; Sharma, Pankaj; Campos, Jaime; Jantunen, Erkki

The development and interest in Industry 4.0 together with rapid development of Cyber Physical Systems has created magnificent opportunities to develop maintenance to a totally new level. The Maintenance 4.0 vision considers massive exploitation of information regarding factories and machines to improve maintenance efficiency and efficacy, for example by facilitating logistics of spare parts, but on the other h...


Signal to background interference in $pp\to t H^-\to t W^- b\bar b$ at the LHC ...

Arhrib, Abdesslam; Benbrik, Rachid; Moretti, Stefano; Santos, Rui; Sharma, Pankaj

We investigate in the Large Hadron Collider (LHC) environment the possibility that sizeable interference effects between a {\sl heavy} charged Higgs boson signal produced via $bg\to tH^-$ (+ c.c.) scattering and decaying via $H^-\to W^- A\to W^- b\bar b$ (+ c.c.) and the irreducible background given by $bg\to t W^- b\bar b$ topologies could spoil current search approaches where the former and latter channels ar...


Signal to background interference in pp -> tH( -)-> tW( - )b(b)over-bar at the ...

Arhrib, Abdesslam; Benbrik, Rachid; Moretti, Stefano; Santos, Rui; Sharma, Pankaj

We investigate in the Large Hadron Collider (LHC) environment the possibility that sizeable interference effects between a heavy charged Higgs boson signal produced via bg -> tH(-) (+c.c.) scattering and decaying via H--> W(-)A -> W- b(b)over-bar (+c.c.) and the irreducible background given by bg -> tW(-) b(b)over-bar topologies could spoil current search approaches where the former and latter channels are trea...


Analysis of shared heritability in common disorders of the brain

Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, Valentina

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common varian...


Optimising charged Higgs boson searches at the Large Hadron Collider across b(b...

Moretti, Stefano; Santos, Rui; Sharma, Pankaj

In the light of the most recent data from Higgs boson searches and analyses, we re-assess the scope of the Large Hadron Collider in accessing heavy charged Higgs boson signals in b¯bW±final states, wherein the contributing channels can be H+→t¯b, hW±, HW±and AW±. We consider a 2-Higgs Doublet Model Type-II and we assume as production mode bg→tH−+c.c., the dominant one over the range MH±≥480GeV, as dictated by b...


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