21 documents found, page 1 of 3
Phytosterols: From Preclinical Evidence to Potential Clinical Applications
Salehi, B; Quispe, C; Sharifi-Rad, J; Martins, N; Nigam, M; Mishra, AP; Konovalov, DA; Orobinskaya, V; Abu-Reidah, IM; Zam, W; Sharopov, F; Venneri, TPhytosterols (PSs) are plant-originated steroids. Over 250 PSs have been isolated, and each plant species contains a characteristic phytosterol composition. A wide number of studies have reported remarkable pharmacological effects of PSs, acting as chemopreventive, anti-inflammatory, antioxidant, antidiabetic, and antiatherosclerotic agents. However, PS bioavailability is a key issue, as it can be influenced by...
Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Mole...
Sharifi-Rad, J; Martins, N; López-Jornet, P; Lopez, EPF; Harun, N; Yeskaliyeva, B; Beyatli, A; Sytar, O; Shaheen, S; Sharopov, F; Taheri, Y; Docea, AOCoumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti-inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase-2 (CK2) inhibitory, antifungal, antiviral, Alzheimer's disease inhibition, neuroprotective, anticonvulsant, phytoalexins, ulcerogenic, and antihypertensi...
Glycyrrhiza Genus: Enlightening Phytochemical Components for Pharmacological an...
Sharifi-Rad, J; Quispe, C; Herrera-Bravo, J; Belén, LH; Kaur, R; Kregiel, D; Uprety, Y; Beyatli, A; Yeskaliyeva, B; Kirkin, C; Özçelik, B; Sen, SThe Glycyrrhiza genus, generally well-known as licorice, is broadly used for food and medicinal purposes around the globe. The genus encompasses a rich pool of bioactive molecules including triterpene saponins (e.g., glycyrrhizin) and flavonoids (e.g., liquiritigenin, liquiritin). This genus is being increasingly exploited for its biological effects such as antioxidant, antibacterial, antifungal, anti-inflammat...
Paving Plant-Food-Derived Bioactives as Effective Therapeutic Agents in Autism ...
Martins, N; Quispe, C; Kirkin, C; Senol, E; Zulug, A; Özçelik, B; Ademiluyi, AO; Oyeniran, OH; Semwal, P; Kumar, M; Sharopov, F; López, V; Les, FAutism spectrum disorder (ASD) is a neurodevelopmental disorder, where social and communication deficits and repetitive behaviors are present. Plant-derived bioactives have shown promising results in the treatment of autism. In this sense, this review is aimed at providing a careful view on the use of plant-derived bioactive molecules for the treatment of autism. Among the plethora of bioactives, curcumin, lute...
Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health
Salehi, B; Machin, L; Monzote, L; Sharifi-Rad, J; Ezzat, SM; Salem, MA; Merghany, RM; El Mahdy, NM; Klllç, CS; Sytar, O; Sharifi-Rad, M; Sharopov, FQuercetin (Que) and its derivatives are naturally occurring phytochemicals with promising bioactive effects. The antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti-Alzheimer's, antiarthritic, cardiovascular, and wound-healing effects of Que have been extensively investigated, as well as its anticancer activity against different cancer cell lines has been recently reported. Que and its derivatives...
Avocado–Soybean unsaponifiables: A panoply of potentialities to be exploited
Salehi, B; Rescigno, A; Dettori, T; Calina, D; Docea, AO; Singh, L; Cebeci, F; Özçelik, B; Bhia, M; Beirami, AD; Sharifi-Rad, J; Sharopov, F; Cho, WCAvocado and soybean unsaponifiables (ASU) constitute vegetable extracts made from fruits and seeds of avocado and soybean oil. Characterized by its potent anti-inflammatory effects, this ASU mixture is recommended to act as an adjuvant treatment for osteoarthritic pain and slow-acting symptomatic treatment of hip and knee osteoarthritis; autoimmune diseases; diffuse scleroderma and scleroderma-like states (e.g....
Diet, lifestyle and cardiovascular diseases: Linking pathophysiology to cardiop...
Sharifi-Rad, J; Rodrigues, CF; Sharopov, F; Docea, AO; Karaca, AC; Sharifi-Rad, M; Karincaoglu, DK; Gülseren, G; Senol, E; Demircan, E; Taheri, YHeart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumpti...
Impact of natural compounds on neurodegenerative disorders: From preclinical to...
Sharifi-Rad, M; Lankatillake, C; Dias, DA; Docea, AO; Mahomoodally, MF; Lobine, D; Chazot, PL; Kurt, B; Tumer, TB; Moreira, AC; Sharopov, FAmong the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their...
Cucurbita plants: From farm to industry
Salehi, B; Sharifi-Rad, J; Capanoglu, E; Adrar, N; Catalkaya, G; Shaheen, S; Jaffer, M; Giri, L; Suyal, R; Jugran, AK; Calina, D; Docea, AOThe Cucurbita genus, a member of Cucurbitaceae family, also known as cucurbits, is native to the Americas. Genus members, like Cucurbita pepo and Cucurbita maxima, have been used for centuries in folk medicine for treating gastrointestinal diseases and intestinal parasites. These pharmacological effects are mainly attributed to their phytochemical composition. Indeed, Cucurbita species are a natural source of c...
Veronica plants-drifting from farm to traditional healing, food application, an...
Salehi, B; Shetty, MS; Kumar, NVA; Živkovic, J; Calina, D; Docea, AO; Emamzadeh-Yazdi, S; Kiliç, CS; Goloshvili, T; Nicola, S; Pignata, G; Sharopov, FThe Veronica genus, with more than 200 species, belongs to the Plantaginaceae family and is distributed over most of the Northern Hemisphere and in many parts of Southern Hemisphere. These plants are traditionally used in medicine for wound healing, in the treatment of rheumatism, and in different human diseases. This paper reviews the chemical composition of some valuable Veronica species, the possibilities Ve...