2 documents found, page 1 of 1
A proposal for new diagnostic criteria for ALS
Shefner, Jeremy M.; Al-Chalabi, Ammar; Baker, Mark R.; Cui, Li-Ying; Carvalho, Mamede; Eisen, Andrew; Grosskreutz, Julian; Hardiman, OrlaSclerosis (ALS) were initially published in 1994 and revised in 2000. Criteria were established because the ‘‘variety of clinical features which may be present early in the course of ALS makes absolute diagnosis difficult and compromises the certainty of diagnosis for clinical research purposes and therapeutic trials.” The original criteria described 4 categories of disease: Definite, Probable, Possible, and Su...
Relationships between slow vital capacity and measures of respiratory function ...
Jackson, Carlayne; Carvalho, Mamede; Genge, Angela; Heiman-Patterson, Terry; Shefner, Jeremy M.; Wei, Jenny; Wolff, Andrew A.Objective: As declining respiratory muscle function commonly leads to disability and death in amyotrophic lateral sclerosis (ALS), respiratory measurements such as slow vital capacity (SVC) may predict disease progression. This study evaluated the relationship between SVC and symptoms measured by the revised ALS Functional Rating Scale (ALSFRS-R). Methods: About 453 ALS placebo-treated patients from the EMPOWER...