3 documents found, page 1 of 1
Synergistic effect of aloe vera hydrogels with imatinib for pH-responsive drug ...
Khan, Aroob Hasan; Shehzad, Adeeb; Pirela, Paola; Atalaia, Mariana; Ruivinho, Beatriz Lourenço; Rashan, Luay; Miran, Waheed; Duarte, Sofia O. D.Imatinib (IM) efficacy as a cancer drug is limited by pharmacokinetic drug resistance developed during systemic circulation before reaching the target site.Hydrogels have attracted attention because of their characteristic physiochemical and biochemical properties, flexibility, and the ability to release drugs directly at target sites causing cancer mitigation. The current study aims at developing Aloe Vera (AV...
Nanomedicine in oncology: diagnostic breakthroughs and therapeutic Frontiers
Shehzad, Adeeb; Alves, Júlia; Ul-Islam, Mazhar; Saidi, Abdullah Khamis Al; Duarte, Sofia O. D.; Khan, Mohammad Sherjeel Javed; Fonte, PedroNanomedicine is a multidisciplinary field, offering significant promises for cancer detection and therapy. Nanoparticles (NPs), nanoprobes and nanobiosensors can be tailored to achieve highly sensitive tumor detection by contrast imaging techniques. The application of directed drug delivery for cancer therapies can be achieved via the formulation and tailoring of drug-loaded nanocarriers. NPs have been employed...
Camptothecin-loaded mesoporous silica nanoparticles functionalized with CpG oli...
Qureshi, Munibah; Viegas, Cláudia; Duarte, Sofia O.D.; Girardi, Michael; Shehzad, Adeeb; Fonte, PedroThe therapeutic efficacy of camptothecin (CPT), a potent antitumor alkaloid, is hindered by its hydrophobic nature and instability, limiting its clinical use in treating cutaneous squamous cell carcinoma (SCC). This study introduces a novel nano drug delivery system (NDDS) utilizing functionalized mesoporous silica nanoparticles (FMSNs) for efficient CPT delivery. The FMSNs were loaded with CPT and subsequently...