10 documents found, page 1 of 1
Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug system...
Wang, Zhao; Olim, Filipe; Sun, Jingjing; Neves, Ana Rute; Mendes, Fátima; Tomás, Helena; Sheng, RuilongUtilizing biocompatible polymers as platforms to covalently conjugate with chemotherapeutics to construct polymer-based prodrugs and their nano drug delivery systems has attracted great attention in recent years. This perspective reviewed state-of-the-arts for polymer-based doxorubicin prodrugs and the related nanodelivery systems, including: (1) pH-responsive polymer-doxorubicin prodrugs/conjugates; (2) pH/red...
A dual-analytes responsive fluorescent probe for discriminative detection of Cl...
Zhu, Beitong; Wu, Xiaoli; Rodrigues, João; Hu, Xichao; Sheng, Ruilong; Bao, Guang-MingHydrazine (N2H4) and ClO− are very harmful for public health, hence it is important and necessary to monitor them in living cells. Herein, we rationally designed and synthesized a dual-analytes responsive fluorescent sensor PTMQ for distinguishing detection of N2H4 and ClO−. PTMQ underwent N2H4-induced double bond cleavage, affording colorimetric and green fluorescence enhancement with good selectivity and a lo...
Self‐assembly of cholesterol‐Doxorubicin and TPGS into Prodrug‐based nanopartic...
Olim, Filipe; Neves, Ana Rute; Vieira, Mariana; Tomás, Helena; Sheng, RuilongDeveloping new easy-to-prepare functional drug delivery nanosystems with good storage stability, low hemotoxicity, as well as controllable drug delivery property, has attracted great attention in recent years. In this work, a cholesterol-based prodrug nanodelivery system is prepared by self-assembly of cholesterol-doxorubicin prodrug conjugates (Chol-Dox) and tocopherol polyethylene glycol succinate (TPGS) usin...
Polysaccharide-based nanomedicines for cancer immunotherapy: a review
Zeng, Yujun; Xiang, Yufan; Sheng, Ruilong; Tomás, Helena; Rodrigues, João; Gu, Zhongwei; Zhang, Hu; Gong, Qiyong; Luo, KuiCancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by immunotherapeutics. However, direct administration of “naked” immunotherapeutic agents (such as nucleic acids, cytokines, adjuvants or antigens without delivery vehicles) often results in: (1) an unsatisfactory efficacy due to suboptimal pharmacokinetics; (2) strong toxic and side effects due to low ...
Prodrug Systems (I): Lipid-based Doxorubicin Prodrugs and their nanodelivery sy...
Olim, Filipe; Neves, Ana Rute; Wang, Zhao; Sun, Jingjing; Tomás, Helena; Sheng, RuilongUsing natural lipids to covalently connect with antitumor agents to construct lipid-based molecular prodrugs and their nanosystems is a promising research frontier for sustainable medicinal chemistry, nanobiotechnology and tumor chemotherapy. This paper reviewed recent progress of lipid-based doxorubicin (molecular) prodrugs and their nanodelivery systems, including lipid-doxorubicin prodrugs, stimuli-responsiv...
Chemical sensors towards environmental toxic molecule monitoring: fluorescent p...
Jiang, Lirong; Wu, Juanjuan; Min, Douyong; Rodrigues, João; Sheng, RuilongThiophenols, a family of important industrial chemicals, is highly toxic for aquatic organisms and human beings. Developing new chemical sensors with the merit of fast, low cost, portable, selective and sensitive, as well as visualizable signal output for efficient detection of thiophenols, is highly desirable. This spotlight article reviewed and discussed the current trend and statement of thiophenols-specific...
Green polymers toward nanobiotechnology(I): synthesis of glycopolypeptides and ...
Wang, Zhao; Neves, Ana Rute; Olim, Filipe; Tomás, Helena; Tang, Shi; Sheng, RuilongHarnessing natural-based renewable molecular resources to construct functional synthetic green polymers is a promising research frontier at the interface of sustainable/green chemistry, polymer chemistry and nanobiotechnology. As natural glycoprotein mimics/analogues and biocompatible building blocks of nanobio- materials, synthetic functional glycopolypeptides and their structural/functional analogues have att...
A fast responsive chromogenic and near-infrared fluorescence lighting-up probe ...
Wu, Juanjuan; Su, Dongdong; Qin, Caiqin; Li, Wei; Rodrigues, João; Sheng, Ruilong; Zeng, LintaoThiophenols as high toxic environmental pollutants are poisonous for animals and aquatic organisms. Therefore, it is indispensable to monitor thiophenols in the environment. Herein, a novel near-infrared fluorescent probe was developed for the detection of thiophenols, which was easily prepared by one-step coupling of 2,4-dini trobenzenesulfonyl chloride with Nile blue. The probe showed a significant near infra...
A selective cascade reaction-based probe for colorimetric and ratiometric fluor...
Wu, Xiaoli; Zeng, Lintao; Chen, Bao-Quan; Zhang, Ming; Rodrigues, João; Sheng, Ruilong; Bao, Guang-MingA novel colorimetric and ratiometric fluorescent probe (Cou-BPO) was readily prepared for specific detection of harmful benzoyl peroxide (BPO). The probe Cou-BPO reacted with BPO via a selective oxidation cleavage-induced cascade reaction of the pinacol phenylboronate group, which resulted in an observable colorimetric and ratiometric fluorescence response towards BPO with a fast response time (o15 min) and a l...
Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors
Shan, Yuebin; Luo, Ting; Peng, Chen; Sheng, Ruilong; Cao, Amin; Cao, Xueyan; Shen, Mingwu; Guo, Rui; Tomás, Helena; Shi, XiangyangDevelopment of highly efficient nonviral gene delivery vectors still remains a great challenge. In this study, we report a new gene delivery vector based on dendrimer-entrapped gold nanoparticles (Au DENPs) with significantly higher gene transfection efficiency than that of dendrimers without AuNPs entrapped. Amine-terminated generation 5 poly(amidoamine) (PAMAM) dendrimers (G5.NH(2)) were utilized as templates...