31 documents found, page 1 of 4
Phosphorus dendron nanomicelles as a platform for combination anti-inflammatory...
Li, Jin; Chen, Liang; Li, Changsheng; Fan, Yu; Zhan, Mengsi; Sun, Huxiao; Mignani, Serge; Majoral, Jean-Pierre; Shen, Mingwu; Shi, XiangyangRationale: Development of novel nanomedicines to inhibit pro-inflammatory cytokine expression and reactive oxygen species (ROS) generation for anti-inflammatory therapy of acute lung injury (ALI) remains challenging. Here, we present a new nanomedicine platform based on tyramine-bearing two dimethylphosphonate sodium salt (TBP)-modified amphiphilic phosphorus dendron (C11G3) nanomicelles encapsulated with antio...
Modulation of Macrophages Using Nanoformulations with Curcumin to Treat Inflamm...
Sun, Huxiao; Zhan, Mengsi; Mignani, Serge; Shcharbin, Dzmitry; Majoral, Jean-Pierre; Rodrigues, João; Shi, Xiangyang; Shen, MingwuCurcumin (Cur), a traditional Chinese medicine extracted from natural plant rhizomes, has become a candidate drug for the treatment of diseases due to its anti-inflammatory, anticancer, antioxidant, and antibacterial activities. However, the poor water solubility and low bioavailability of Cur limit its therapeutic effects for clinical applications. A variety of nanocarriers have been successfully developed to ...
Engineered non-invasive functionalized dendrimer/dendron-entrapped/complexed go...
Mignani, Serge; Shi, Xiangyang; Ceña, Valentin; Rodrigues, João; Tomás, Helena; Majoral, Jean-PierreNanomedicine represents a very significant contribution in current cancer treatment; in addition to surgical intervention, radiation and chemotherapeutic agents that unfortunately also kill healthy cells, inducing highly deleterious and often life-threatening side effects in the patient. Of the numerous nanoparticles used against cancer, gold nanoparticles had been developed for therapeutic applications. Inter ...
Polyethylenimine nanogels incorporated with ultrasmall iron oxide nanoparticles...
Zou, Yu; Li, Du; Wang, Yue; Ouyang, Zhijun; Peng, Yucheng; Tomás, Helena; Xia, Jindong; Rodrigues, João; Shen, Mingwu; Shi, XiangyangDevelopment of versatile nanoplatforms for cancer theranostics remains a hot topic in the area of nanomedicine. We report here a general approach to create polyethylenimine (PEI)-based hybrid nanogels (NGs) incorporated with ultrasmall iron oxide (Fe3O4) nanoparticles (NPs) and doxorubicin for T1-weighted MR imaging guided chemotherapy of tumors. In this study, PEI NGs were first prepared using an inverse emuls...
Superstructured poly(amidoamine) dendrimer-based nanoconstructs as platforms fo...
Song, Cong; Shen, Mingwu; Rodrigues, João; Mignani, Serge; Majoral, Jean-Pierre; Shi, XiangyangPoly(amidoamine) (PAMAM) dendrimers, as a family of synthetic macromolecules with highly branched interiors, abundant surface functional groups, and well-controlled architecture, have received immense scientific and technological interests for a range of biomedical applications, in particular cancer nanome dicine. However, due to the drawbacks of single-generation dendrimers with a quite small size (e.g., gen e...
Dendrimers toward translational nanotherapeutics: concise key step analysis
Mignani, Serge; Shi, Xiangyang; Rodrigues, João; Roy, René; Muñoz-Fernández, Ángeles; Ceña, Valentin; Majoral, Jean PierreThe goal of nanomedicine is to address specific clinical problems optimally, to fight human diseases, and to find clinical relevance to change clinical practice. Nanomedicine is poised to revolutionize medicine via the development of more precise diagnostic and therapeutic tools. The field of nanomedicine encompasses numerous features and therapeutic disciplines. A plethora of nanomolecular structures have been...
Morpholino-functionalized phosphorus dendrimers for precision regenerative medi...
Li, Aijun; Fan, Yu; Cao, Xueyan; Chen, Liang; Wang, Le; Alves, Carla S.; Mignani, Serge; Majoral, Jean Pierre; Tomás, Helena; Shi, XiangyangA novel bioactive macromolecule based on morpholino-functiona lized phosphorus dendrimers (generation 2, G2-Mor+ ) was devel oped for osteogenic differentiation of mesenchymal stem cells (MSCs). Interestingly, through in vitro tests, it was shown that G2- Mor+ dendrimer can strongly promote the transformation of MSCs into osteoblasts, which implies the potential application of phos phorus de medicine.
Exploration of biomedical dendrimer space based on in-vivo physicochemical para...
Mignani, Serge; Rodrigues, João; Roy, René; Shi, Xiangyang; Ceña, Valentin; El Kazzouli, Saïd; Majoral, Jean-PierreIn nanomedicine, the widespread concern of nanoparticles in general, and dendrimers, in particular, is the analysis of key in-vivo physicochemical parameters to ensure the preclinical and clinical development of 'safe' bioactive nanomaterials. It is clear that for biomedical applications, biocompatible dendrimers, used as nanocarriers or active per se, should be devoid of toxicity and immunogenicity, and have a...
Zwitterion-functionalized dendrimer-entrapped gold nanoparticles for serum-enha...
Xiong, Zhijuan; Alves, Carla S.; Wang, Jianhua; Li, Aijun; Liu, Jinyuan; Shen, Mingwu; Rodrigues, João; Tomás, Helena; Shi, XiangyangWe demonstrate a novel serum-enhanced gene delivery approach using zwitterion-functionalized dendrimer-entrapped gold nanoparticles (Au DENPs) as a non-viral vector for inhibition of cancer cell metastasis in vitro. Poly(amidoamine) dendrimers of generation 5 decorated with zwitterion carboxybe taine acrylamide (CBAA) and lysosome-targeting agent morpholine (Mor) were utilized to entrap gold NPs. We show that b...
Exploration of biomedical dendrimer space based on in-vitro physicochemical par...
Mignani, Serge; Rodrigues, João; Roy, René; Shi, Xiangyang; Ceña, Valentin; El Kazzouli, Saïd; Majoral, Jean-PierreDendrimers are highly branched, star-shaped macromolecules with nanometer-scale dimensions that can be readily modified with a range of functional groups, thus modifying their physicochemical and biological properties. In nanomedicine, dendrimers can be used as vectors for the targeted delivery strategy of a variety of biologically active agents or can be used as drug per se. In the future, it will be necessary...