24 documents found, page 1 of 3
Determination of Antiepileptics in Biological Samples—A Review
Martinho, João; Simão, Ana Y.; Barroso, Mário; Gallardo, Eugenia; Rosado, TiagoEpilepsy remains a disease that affects many people around the world. With the development of new drugs to treat this condition, the importance of therapeutic drug monitoring continues to rise and remains a challenge for the medical community. This review article explores recent advances in the detection of antiepileptic drugs across various sample types commonly used for drug monitoring, with a focus on their ...
Characterisation of Cannabis-Based Products Marketed for Medical and Non-Medica...
Pires, Bruno; Oliveira, Patrik; Simão, Ana Y.; Reis, João; Ramos, Sofia; Duarte, Ana Paula; Margalho, Cláudia; Rosado, Tiago; Barroso, MárioCannabis-based products have gained attention in recent years for their perceived therapeutic benefits (with cannabinoids such as THC and CBD) and widespread availability. However, these products often lack accurate labelling regarding their cannabinoid content. Our study, conducted with products available in Portugal, revealed significant discrepancies between label claims and actual cannabinoid compositions. ...
Microextraction action by packed sorbent in forensic drug analysis
Rosado, Tiago; Pelixo, Rodrigo; Pires, Bruno; Catarro, João Miguel; Rosendo, Luana M.; Brinca, Ana T.; Antunes, Mónica; Soares, Sofia; Simão, Ana Y.Microextraction by packed sorbent (MEPS) efficiently combines extraction, pre-concentration, and cleanup in a single device comprising two parts: the MEPS syringe and the packed sorbent bed1. MEPS has been used for several bioanalytical applications, including extraction of endogenous metabolites, biomarkers, and drugs from biological samples. It is particularly useful in metabolomics and pharmacokinetic studie...
Desenvolvimento de um método por LC/MS-MS para a determinação de novas substânc...
Simão, Ana Y.; Tokuyama, Paula; Zampieri, Gianfranco; Rocha, Vivian; Cidade, Lucas; Madruga, Clarice; Isicawa, Kátia; Andraus, Maristela; Barroso, MárioAs novas substâncias psicoativas (NPS) são desenvolvidas para mimetizar os efeitos psicotrópicos das drogas clássicas, e sua presença tem vindo a aumentar no mercado de drogas. Estes compostos são facilmente acessíveis (por exemplo, online) e geralmente não são regulamentados pelas políticas internacionais de drogas. Este trabalho descreve o desenvolvimento de um método sensível e específico por LC-MS/MS para d...
Evaluation of hair hydrolysis and MEPS columns for the detection of amphetamine...
Pires, Bruno; Simão, Ana Y.; Rosado, Tiago; Gallardo, Eugenia; Barroso, MárioIntroduction: Different extraction and cleanup procedures have been used to identify amphetamines in hair samples. The microextraction by packed sorbent (MEPS), a miniaturized approach of the classic solid-phase extraction (SPE), has only been used so far to determine the presence of amphetamine (AMP) and methamphetamine (MAMP) in hair. The aim of this work was to evaluate different hair sample extraction condi...
Determination of amphetamine-related drugs in hair using MEPS as sample clean-up
Pires, Bruno; Simão, Ana Y.; Rosado, Tiago; Gallardo, Eugenia; Barroso, MárioIntroduction and aims: Different extraction and clean-up protocols have been used for amphetamine-related compounds determination in hair. Microextraction by packed sorbent (MEPS) is a miniaturized version of solidphase extraction (SPE) which has been applied to determine a number of drugs in hair (e.g., opiates, cocaine, ketamine, etc.) [1-4]. However, concerning amphetamine-related drugs, MEPS has only been u...
Optimization and validation of an analytical method for the determination of op...
Simão, Ana Y.; Monteiro, Catarina; Marques, Hernâni; Rosado, Tiago; Barroso, Mário; Andraus, Maristela; Gallardo, EugeniaAccording to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), approximately 1.3 million individuals have used opiates, both for medical and illicit purposes1, presenting a significant public health challenge2,3. To address this issue, methods for quantifying these substances are needed. Urine is a commonly employed matrix in clinical and forensic toxicological analyses due to its ease of co...
Sensors in the Detection of Abused Substances in Forensic Contexts: A Comprehen...
Rosendo, Luana M.; Antunes, Mónica; Simão, Ana Y.; Brinca, Ana Teresa; Catarro, Gonçalo; Pelixo, Rodrigo; Martinho, João; Pires, Bruno; Soares, Sofiaorensic toxicology plays a pivotal role in elucidating the presence of drugs of abuse in both biological and solid samples, thereby aiding criminal investigations and public health initiatives. This review article explores the significance of sensor technologies in this field, focusing on diverse applications and their impact on the determination of drug abuse markers. This manuscript intends to review the tran...
Determination of amphetamine-type psychostimulants in hair samples using MEPS a...
Pires, Bruno; Simão, Ana Y.; Rosado, Tiago; Gallardo, Eugenia; Barroso, MárioNumerous protocols for the analysis of amphetamine-type psychostimulants (ATS) in hair have been employed over the years. Microextraction by packed sorbent (MEPS), a downsized version of solid-phase extraction (SPE), has been effectively applied in hair drug analysis, including substances like opiates, cocaine, and ketamine. However, concerning ATS, MEPS has primarily been used to the determination of amphetami...
Microextraction by Packed Sorbent as a Clean-up Approach for the Determination ...
Simão, Ana Y.; Oliveira, Patrik; Rosendo, Luana; Rosado, Tiago; Andraus, Maristela; Barroso, Mário; Gallardo, EugeniaThe use of new psychoactive substances has been increasing and constitutes a social and public health problem, and hence, toxicological analysis has become of utmost importance for the detection of such substances. In this article, we present the development and full validation of a simple, user and environmentally friendly, cheap and suitable method for the determination of ketamine and its main metabolite nor...