3 documents found, page 1 of 1
The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfuncti...
Batalha, Vânia; Ferreira, Diana; Coelho, Joana E; Valadas, Jorge S.; Gomes, Rui; Temido Ferreira, Mariana; Shmidt, Tatiana; Baqi, Younis; Buée, LucCaffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A2A receptor (A2AR), which is upregulated in the human forebrain of aged and Alzheimer's disease (AD) patients. We have previously shown that an anti-A2AR therapy reverts age-like memory deficits, by reestablishment of the hypothalamic-pituitary-adrenal (HPA) axis feedback and corticosterone circadian lev...
Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locom...
Coelho, Joana E.; Alves, Pedro; Canas, Paula M.; Valadas, Jorge S.; Shmidt, Tatiana; Batalha, Vânia L.; Ferreira, Diana G.; Ribeiro, Joaquim A.Adenosine A2A receptors (A2AR) are a sub-type of receptors enriched in basal ganglia, activated by the neuromodulator adenosine, which interact with dopamine D2 receptors. Although this reciprocal antagonistic interaction is well-established in motor function, the outcome in dopamine-related behaviors remains uncertain, in particular in depression and anxiety. We have demonstrated an upsurge of A2AR associated ...
Overexpression of Adenosine A2A receptors in rats: effects on depression, locom...
Coelho, Joana E; Alves, Pedro Nascimento; Canas, Paula M.; Valadas, Jorge S.; Shmidt, Tatiana; Batalha, Vânia; Ferreira, Diana G.; Ribeiro, Joaquim A.Adenosine A2A receptors (A2AR) are a sub-type of receptors enriched in basal ganglia, activated by the neuromodulator adenosine, which interact with dopamine D2 receptors. Although this reciprocal antagonistic interaction is well-established in motor function, the outcome in dopamine-related behaviors remains uncertain, in particular in depression and anxiety. We have demonstrated an upsurge of A2AR associated ...