6 documents found, page 1 of 1
Antheraea pernyi silk nanofibrils with inherent RGD motifs accelerate diabetic ...
Duan, Lian; Liu, Ga; Liao, Fuying; Xie, Chunyu; Shi, Jiahao; Yang, Xiao; Zheng, Fan; Reis, R. L.; Kundu, Subhas C; Xiao, BoThe chronic inflammation and matrix metalloprotease (MMP)-induced tissue degradation significantly disrupt re-epithelization and delay the healing process of diabetic wounds. To address these issues, we produced nanofibrils from Antheraea pernyi (Ap) silk fibers via a facile and green treatment of swelling and shearing. The integrin receptors on the cytomembrane could specifically bind to the Ap nanofibrils (Ap...
Injectable dual-network hydrogel for phototherapy and immunomodulation in the t...
Bao, Shengfei; Jiang, Aodi; Peng, Li; Liao, Fuying; Liu, Ga; Chen, Li; Zhou, Peng; Zhu, Zhen; Reis, R. L.; Kundu, Subhas C; Duan, Lian; Xiao, BoContinuous invasion and infection of drug-resistant bacteria leads to chronic inflammation and ulcers in skin wounds, which hinders wound healing and even results in sepsis. Here, we constructed a multifunctional injectable hydrogel (GA/PIOP/SF) that was composed of a synthesized porous ionic organic polymer (PIOP) with photothermal and photodynamic therapy (PDT/PTT) capacities to kill bacteria, a bioactive sma...
CaO2-Cu2O micromotors accelerate infected wound healing through antibacterial f...
Liu, Ga; Zu, Menghang; Wang, Lingshuang; Xu, Cheng; Zhang, Jiamei; Reis, R. L.; Kundu, Subhas C; Xiao, Bo; Duan, Lian; Yang, XiaoDuring the wound tissue healing process, the relatively weak driving forces of tissue barriers and concentration gradients lead to a slow and inefficient penetration of bioactive substances into the wound area, consequently showing an impact on the effectiveness of deep wound healing. To overcome these challenges, we constructed biocompatible CaO2–Cu2O “micromotors”. These micromotors reacted with the fluids at...
Tissue adhesives based on chitosan for skin wound healing: Where do we stand in...
Wang, Lingshuang; Qiu, Libin; Li, Baoyi; Reis, R. L.; Kundu, Subhas C; Duan, Lian; Xiao, Bo; Yang, XiaoChitosan has been commonly used as an adhesive dressing material due to its excellent biocompatibility, degradability, and renewability. Tissue adhesives are outstanding among wound dressings because they can close the wound, absorb excess tissue exudate from the wound site, provide a moist environment, and act as a carrier for loading various bioactive molecules. They have been widely used in both preclinical ...
Transparent silk fibroin film-facilitated infected-wound healing through antiba...
Zhang, Jiamei; Wang, Lingshuang; Xu, Cheng; Cao, Yingu; Liu, Shengsheng; Reis, R. L.; Kundu, Subhas C; Yang, Xiao; Xiao, Bo; Duan, LianThe clinical application of regenerated silk fibroin (RSF) films for wound treatment is restricted by its undesirable mechanical properties and lack of antibacterial activity. Herein, different pluronic polymers were introduced to optimize their mechanical properties and the RSF film with 2.5% pluronic F127 (RSFPF127) stood out to address the above issues owing to its satisfactory mechanical properties, hydroph...
Bioinspired polyacrylic acid-based dressing: wet adhesive, self-healing, and mu...
Wang, Lingshuang; Duan, Lian; Liu, Ga; Sun, Jianfeng; Shahbazi, Mohammad-Ali; Kundu, Subhas C; Reis, R. L.; Xiao, Bo; Yang, XiaoPolyacrylic acid (PAA) and its derivatives are commonly used as essential matrices in wound dressings, but their weak wet adhesion restricts the clinical application. To address this issue, a PAA-based coacervate hydrogel with strong wet adhesion capability is fabricated through a facile mixture of PAA copolymers with isoprenyl oxy poly(ethylene glycol) ether and tannic acid (TA). The poly(ethylene glycol) segm...