25 documents found, page 1 of 3
Discovery of 2,9-diaryl-6-carbamoylpurines as a novel class of antitubercular a...
Correia, Carla; Leite, Ana Claúdia; Fraga, Alexandra G.; Proença, M. Fernanda R. P.; Pedrosa, Jorge; Carvalho, M. AliceA series of novel 9-alkyl/aryl-2-aryl-6-carbamoylpurines were synthesized, and their activity against $\text{Mycobacterium tuberculosis}$ strain $\text{H}37\text{Rv}$ was assessed. The $\text{SAR}$ analysis on the first set of derivatives, with an alkyl or aryl unit at $\text{N}$-$9$ and a phenolic unit at $\text{C}$-$2$, showed that the activity depends on the purine ring substituents at $\text{N}$-$9$ and $\t...
2-Aryladenine derivatives as a potent scaffold for adenosine receptor antagonis...
Areias, Filipe; Correia, Carla; Rocha, Ashly; Teixeira, Sofia; Castro, Marián; Brea, Jose; Hu, Huabin; Carlsson, Jens; Loza, Maria I.A set of 2-aryl-9-H or methyl-6-morpholinopurine derivatives were synthesized and assayed through radioligand binding tests at human A<inf>1</inf>, A<inf>2A</inf>, A<inf>2B</inf>, and A<inf>3</inf> adenosine receptor subtypes. Eleven purines showed potent antagonism at A<inf>1</inf>, A<inf>3</inf>, dual A<inf>1</inf>/A<inf>2A</inf>, A<inf>1</inf>/A<inf>2B</inf>, or A<inf>1</inf>/A<inf>3</inf> adenosine receptor...
Trabalho Livre nº 30 - Consulta de Feridas Complexas – análise de custo benefíc...
Afonso, Énio; Lúcia, Ana; Correia, CarlaA incidência de úlceras crónicas na população é crescente e representa um peso significativo para os sistemas de saúde, em termos financeiros, e para os doentes, em termos de qualidade de vida. O conhecimento necessário para o tratamento deste tipo de feridas é transversal a várias áreas da medicina. A concentração desse conhecimento no momento do tratamento é, por isso, um desafio. Apenas a sua conjugação simu...
Regioselective synthesis of 2-Aryl-5-cyano-1-(2-hydroxyaryl)-1H-imidazole-4-car...
Pedroso de Lima, Fabio; Lence, Emilio; Suarez de Cepeda, Pilar; Correia, Carla; Carvalho, M. Alice; Gonzalez-Bello, ConcepcionThe reactivity of the diaminomaleonitrile-based imines containing hydroxyphenyl substituents with diverse aromatic aldehydes has been explored for the synthesis of novel highly substituted nitrogen heterocycles, which are considered privileged scaffolds in drug discovery. We report here a simple and efficient method for the regiocontrolled synthesis of a variety of 2-aryl-5cyano-1-(2-hydroxyaryl)-1H-imidazole-4...
2-Aryladenine derivatives as a potent scaffold for A1, A3 and dual A1/A3 adenos...
Areias, Filipe; Correia, Carla; Rocha, Ashly; Brea, José; Castro, Marián; Loza, Maria I.; Proença, M. Fernanda R. P.; Carvalho, M. AliceFrom a collection containing more than 1500 academic compounds, in silico screening identified a hit for the human A1 adenosine receptor containing a new purine scaffold. To study the structure activity relationships of this new chemical series for adenosine receptors, a library of 24 purines was synthesized and tested in radioligand binding assays at human A1, A2A, A2B and A3 adenosine receptor subtypes. Fourt...
Exploring a capacity to screen of the european portuguese version of the 15-ite...
Apóstolo, João; Bobrowicz-Campos, Elzbieta; Reis, Ivo; Henriques, Susana; Correia, Carla; Henriques, SusanaThe aim of this study was to analyze the screening performance of the European Portuguese version of the 15-item Geriatric Depression Scale (GDS-15) against DSM-5 diagnostic criteria for major depressive episode. The study was multicentre and involved 139 older adults recruited in the context of primary healthcare. Twenty-three participants were diagnosed with clinical depression. Sensitivity and specificity fo...
Can we use old Harris and Bennedict formula for determine resting energy expend...
Correia, Carla; Fábio, Martins; Mendes, Lino; Moreira, Ana CatarinaBackground: Anorexia Nervosa (AN) is characterized by a severe restriction of energy intake that results in a significantly low body weight reflecting depletion in body compartments, as well as a decrease in Resting Energy Expenditure (REE). Overfeeding is of great concern when feeding these patients to establish an adequate amount of energy will assure recovery of nutritional status and prevent complications. ...
Saúde Escolar em Construção: Que Projetos?
Rocha, Amarílis; Correia, Carla; Pestana, Leonor; Bento, Manuela; Preto, Olinda; Lobão, SandraO conceito atual de saúde, no âmbito do processo de desenvolvimento humano, depende do projeto de vida de cada um, do seu sentido de felicidade, da sua forma específica de estar no mundo e do seu esforço solidário para compreender e respeitar o universo (Rodrigues, 1995). Acompanhando esta mudança de paradigma, o conceito de saúde escolar tradicional, centrado na prevenção da doença, foi substituído. Pondo-se ...
Cidades educadoras: do conceito ao potencial solidário na prevenção dos maus-tr...
Ribeiro, Esperança Jales; Coelho, Anabela; Correia, Carla; Luz, Dina; Oliveira, Elisa; Gomes, RuiObservamos hoje um mundo global, em constante mudança, onde as políticas sociais vão determinando as dinâmicas das sociedades ao mesmo tempo que procuram responder aos desafios colocados pela permanente instabilidade social. Enquanto o estado de direito social revela uma preocupação crescente com o investimento em políticas do bem-estar dos seus cidadãos a cidade assume, enquanto espaço onde os homens convivem ...
Therapeutic education, the premise of adherence to the type 2 diabetes therapeu...
Albuquerque, Carlos; Correia, Carla; Ferreira, Manuela; Duarte, JoãoBackground: type 2 diabetes mellitus includes changes in lifestyle in its etiology of prevention, but the evidence is clear —even when people know what to do and what they want to do, they simply do not adopt adherence behaviors. Structured education will allow improving not only metabolic control, but also the adjustment process to a new situation of disease, as well as to develop the patient’s skills in order...