2 documents found, page 1 of 1
Tumor necrosis factor prevents Candida albicans biofilm formation
Rocha, Francisco Airton Castro; Alves, Anelise Maria Costa Vasconcelos; Rocha, Marcos Fábio Gadelha; Cordeiro, Rossana de Aguiar CordeiroCandida species are commensals but some develop biofilms in prosthetic materials and host surfaces that may represent up to 30% of deaths related to infections, particularly in immunosuppressed patients. Tumor necrosis factor (TNF) exhibits a plethora of functions in host defense mechanisms whereas excessive release of TNF in inflammation promotes tissue damage. Cytokines released in an inflammatory milieu may ...
Anti-inflammatory and immunomodulatory effect of an extract of coccidioides pos...
Pinto, Ana Carolina Matias Dinelly; Cordeiro, Rossana de Aguiar; Sidrim, José Julio Costa; Leite, Ana Karine Rocha de MeloTrying to surpass host defenses, fungal infections alter the immune response. Components from nonpathogenic fungi present therapeutic anti-inflammatory and immunomodulating activities. This study reveals that proteins present in a Coccidioides posadasii extract provide anti-inflammatory benefit in experimental arthritis. Zymosan was given intra-articularly to rats and mice, and groups were pretreated with C. po...