We thank the MTD sensor team for providing the SiPMs and sensor modules used in the measurements and more generally the MTD project for all the support provided to the TOFHIR2 development. We also thank the CMS collaboration for creating the conditions that made this work possible. We thank the Microelectronics Group at CERN for all the support and advice in the development of TOFHIR2, as well as for making ava...
Funding Information: This research was funded by FEDER funds through the COMPETE 2020 Programme and National Funds through the FCT (Portuguese Foundation for Science and Technology) under the scope of the Doctoral Grant No. DFA/BD/8335/2020. Publisher Copyright: © 2022 Author(s).; This study explores the resistive switching phenomena present in 4 μm2 amorphous Indium-Gallium-Zinc Oxide (IGZO) memristors. Despit...
Biosimilars are new and more affordable similar versions of previously approved reference biological drugs. Following the approval of the first monoclonal antibody biosimilar in 2013, the Portuguese Society of Rheumatology issued a position paper on the use of biosimilars in rheumatic conditions covering efficacy, safety, extrapolation, interchangeability, substitution and pharmacovigilance. However, as this is...
Objective: To update the recommendations for the treatment of rheumatoid arthritis (RA) with biological therapies, endorsed by the Portuguese Society of Rheu -matology (SPR). Methods: These treatment recommendations were formulated by Portuguese rheumatologists based on litera -ture evidence and consensus opinion. At a national meeting the 11 recommendations were discussed and updated. The document resulting fr...
Background: Methotrexate (MTX) is the first-line drug in the treatment of rheumatoid arthritis (RA) and the most commonly prescribed disease modifying antirheumatic drug. Moreover, it is also used as an adjuvant drug in patients under biologic therapies, enhancing the efficacy of biologic agents. Objectives: To review the literature and update the Portuguese recommendations for the use of MTX in rheumatic disea...
Biosimilars are new and more affordable similar versions of previously approved reference biological drugs. Following the approval of the first monoclonal antibody biosimilar in 2013, the Portuguese Society of Rheumatology issued a position paper on the use of biosimilars in rheumatic conditions covering efficacy, safety, extrapolation, interchangeability, substitution and pharmacovigilance. However, as this is...
The availability of population-specific normative data regarding disease severity measures is essential for patient assessment. The goals of the current study were to characterize the pattern of ankylosing spondylitis (AS) in Portuguese patients and to develop reference centile charts for BASDAI, BASFI, BASMI and mSASSS, the most widely used assessment tools in AS. AS cases were recruited from hospital outpatie...