9 documents found, page 1 of 1
Pumilacidins A-E from Sediment-Derived Bacterium Bacillus sp. 4040 an Their Ant...
Oliveira,Josiane A. M. de; Williams,David E.; Andersen,Raymond J.; Sarragiotto,Maria H.; Baldoqui,Debora C.Marine strains of Bacillus are known to produce secondary metabolites different from that accumulated by their terrestrial counterparts, for example, lipopeptides such as surfactins, iturins and fengycins, which exhibit a variety of biological activities. Another important class of lipopeptides are pumilacidins, identified specially from Bacillus pumilus strains, usually by using liquid chromatography-mass spec...
Synthesis, Antileishmanial Activity and Spin Labeling EPR Studies of Novel β-Ca...
Baréa,Paula; Paula,Jéssica C. de; Alonso,Laís; Oliveira,Aline R. de; Costa,Willian F. da; Alonso,Antonio; Nakamura,Celso V.; Sarragiotto,Maria H.A series of novel 1-(substituted-phenyl)-3-(4,5-dihydro-1,3-oxazol-2-yl)-9H-β-carboline (8a-8i) and 1-(substituted-phenyl)-3-(5,6-dihydro-4H-1,3-oxazin-2-yl)-9H-β-carboline (9a-9h) derivatives, as well as their respective N-(chloroalkyl)-1-(substituted-phenyl)-9H-β-carboline-3-carboxamide precursors (6a-6i and 7a-7h), were synthesized and evaluated for their in vitro antileishmanial activity against promastigot...
Synthesis, in vitro Antiproliferative and Anti-Mycobacterium tuberculosis Activ...
Moreira,Flora M. F.; Croda,Julio; Sarragiotto,Maria H.; Foglio,Mary A.; Ruiz,Ana L. T. G.; Carvalho,João E.; Formagio,Anelise S. N.A series of β-carboline derivatives with amino or guanidinium were synthesized and evaluated in vitro against anti-Mycobacterium tuberculosis and for antiproliferative activities against nine human cancer cell lines. The compounds 1-(4-hydroxyphenyl)-3-carboxamide(ethylamine) β-carboline (24.9 µg mL-1) and 1-(4-methoxyphenyl)-3-carboxamide(ethylamine) β-carboline (26.9 µg mL-1) were the most active against M. T...
Bioactive Indole Alkaloids from Croton echioides
Novello,Claudio R.; Marques,Luís C.; Pires,Murilo E.; Kutschenco,Ana P.; Nakamura,Celso V.; Nocchi,Samara; Sarragiotto,Maria H.; Mello,João C. P.Bioguided fractionation of a hydroethanolic extract from the stem bark of Croton echioides Baill. led to isolation of the new indole alkaloid N-trans-feruloyl-3,5-dihydroxyindolin-2-one as a stereoisomeric mixture and the known alkaloids N-trans-p-coumaroyl-tryptamine, N-trans-p-coumaroyl-5-hydroxytryptamine, N-trans-4-methoxy-cinnamoyl-5-hydroxytryptamine, N-trans-feruloyl-5-hydroxytryptamine (moschamine), fro...
Morphoanatomy and pharmacognostic study of the wood of Croton echioides, the No...
Novello,Cláudio R.; Marques,Luís C.; Miyazaki,Cristine R.; Milaneze-Gutierre,Maria A.; Carneiro-Torres,Daniela S.; Sarragiotto,Maria H.Croton echioides Baill., Euphorbiaceae, is a small tree found in Bahia, Northeastern Brazil. Its stem bark has been widely sold as an aphrodisiac and tonic, as a substitute for the roots of Ptychopetalum olacoides Benth. Olacaceae, the Amazon Muira Puama or Marapuama, and C. echioides is characterized as the "Northeastern Marapuama". This contribution describes a morphoanatomical analysis and pharmacognostic st...
Estudo fitoquímico e avaliação da toxicidade frente a Artemia salina e da ativi...
Domingues,Elaine A.; Nakamura,Celso V.; de Souza,Maria C.; Teixeira,Tatiane S.; Peixoto,Juliana L. B.; Sarragiotto,Maria H.; Vidotti,Gentil J.O estudo fitoquímico das folhas de Calycorectes psidiiflorus (O. Berg) Sobral, Myrtaceae, resultou no isolamento e identificação de: sesquiterpeno [8-hidroxicalameneno (1)], triterpenos [α-amirina (2a) e β-amirina (2b)], flavonóide [3-O-α-ramnopiranosil-7-O-bglucopiranosil canferol (3)], e alcalóide [1,2,3,4-tetraidro-1-metil-β-carbolina (4)]. As estruturas das substâncias isoladas foram elucidadas com base nos...
Evaluation of the molluscicidal and Schistosoma mansoni cercariae activity of C...
Medina,Janaina M.; Peixoto,Juliana L. B.; Silva,Adriano A.; Haraguchi,Shirani K.; Falavigna,Dina L. M.; Zamuner,Maria L. M.; Sarragiotto,Maria H.Lethality of the extracts of Croton floribundus (Euphorbiaceae), a medicinal plant from south Brazil, and of the kaurenoic acid, an isolated compound, and two of its derivatives against adult Biomphalaria glabrata snails, Schistosoma mansoni cercariae and Artemia salina Leach. brine shrimp larvae are reported. Both extracts and the isolated compound showed significant molluscicidal and cercaricidal activities a...
Synthesis and antiproliferative activity of novel limonene derivatives with a s...
Figueiredo,Isis M.; Santos,Luciane V. dos; Costa,Willian F. da; Carvalho,João E. de; Silva,Cleuza C. da; Sacoman,Juliana L.; Kohn,Luciana K.A series of R-(+)-limonene derivatives bearing a substituted thiourea moiety (3-13) and five S-methyl analogs (14-18) were synthesized and evaluated for their in vitro antiproliferative activity against human cancer cell lines. Compounds bearing aromatic substituents (3-6) exhibit cytotastic activity in the full panel of cell lines tested, with GI50 values in the range of 2.5 to 24 µmol L-1. Compounds 3, 10, 12...
Qualitative determination of indole alkaloids of Tabernaemontana fuchsiaefolia ...
Zocoler,Marcos A.; Oliveira,Arildo J. B. de; Sarragiotto,Maria H.; Grzesiuk,Viviane L.; Vidotti,Gentil J.This paper describes a fast and efficient procedure to separate and identify indole alkaloids from the ethanolic extract of Tabernaemontana fuchsiaefolia (Apocynaceae). The alkaloidal fractions obtained from ethanolic extracts of leaves and stem barks and root barks were fractioned and analyzed by Thin-Layer Chromatography (TLC) and by Gas Chromatography coupled to Mass Spectrometry (GC-MS). The following indol...