18 documents found, page 1 of 2
Metabolism-targeted therapy in NSCLC – A new theranostics inhalation approach u...
Mendes, Cindy; Martins, Filipa; Granja, Sara; Gonçalves, Joana; Barros, Hélio; Casimiro, Teresa; Aguiar-Ricardo, Ana; Silva, Fernanda; Abreu, BrunaFunding Information: The institutions are funded by Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNO-VA4Health (UIDB/04462/2020 and UIDP/04462/2020), to MOSTMICRO-ITQB (UIDB/04612/2020 and UIDP/04612/2020) and the Associated Laboratory LS4FUTURE (LA/P/0087/2020). During the course of PhD, Cindy Mendes was funded by Lig...
BRD9 status is a major contributor for cysteine metabolic remodeling through MS...
Hipólito, Ana; Xavier, Renato; Brito, Cheila; Tomás, Ana; Lemos, Isabel; Cabaço, Luís C.; Silva, Fernanda; Oliva, Abel; C. Barral, DuartePublisher Copyright: Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.; Cutaneous melanoma (CM) is the most aggressive skin cancer, showing globally increasing incidence. Hereditary CM accounts for a significant percentage (5-15 %) of all CM cases. However, most familial cases remain without a known genetic cause. Even though, BRD9 has been associated to CM as a susceptibility gene. ...
Programmed death-ligand 1 (PD-L1) expression in cervical intraepithelial neopla...
Brito, Maria José; Sequeira, Pedro; Quintas, Ana; Silva, Iryna; Silva, Fernanda; Martins, Catarina; Félix, AnaFunding: Open access funding provided by FCT|FCCN (b-on).; Programmed death-ligand 1 (PD-L1) is overexpressed in cervical carcinoma, hindering tumor destruction. The aim of this study was to assess PD-L1 expression by immunohistochemistry in cervical squamous cell carcinoma (SCC) and squamous intraepithelial lesions (SILs) from human immunodeficiency virus–positive (HIV+) and human immunodeficiency virus-negati...
The impact of formalin fixation in the elemental content of tissues
Silva, João; Castelhano, Ricardo; Silva, Fernanda; Santos, José Paulo; Félix, Ana; Cruz, João; Machado, Jorge; Pessanha, SofiaThis work has been financially supported by Fundação para a Ciência e a Tecnologia through the LIBPhys funding UID/FIS/ 04559/2020. João Silva PhD grant BDANA/01513/2023 . Publisher Copyright: © 2024 The Author(s); Formalin fixation is a crucial step in the preparation of tissue samples for anatomic pathology studies, however, research showed that prolonged formalin fixation, can alter the elemental composition...
Peripheral Blood Serum NMR Metabolomics Is a Powerful Tool to Discriminate Beni...
Nunes, Sofia C.; Sousa, Joana; Silva, Fernanda; Silveira, Margarida; Guimarães, António; Serpa, Jacinta; Félix, Ana; Gonçalves, Luís G.Funding Information: The institutions are funded by Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), to MOSTMICRO-ITQB (UIDB/04612/2020 and UIDP/04612/2020) and the Associated Laboratory LS4FUTURE (LA/P/0087/2020). The NMR data was acquired at CERMAX, ITQB-NOVA, Oeiras, P...
Evaluation of the influence of the formalin fixation time on the elemental cont...
Pessanha, Sofia; Veiga, Alexandre; Doutel, Delfim; Silva, Fernanda; Silva, João; Carvalho, Patrícia M.; Barbosa, Sofia; Santos, José Paulo; Félix, AnaFunding Information: This work was partially supported by the research centre grant UID/FIS/04559/2021 to LIBPhys-UNL from the FCT/MCTES/PIDDAC , Portugal. Publisher Copyright: © 2023 The Authors; One of the most widely used methods for tissue preservation and fixative during transportation is the conservation in formalin during variable amounts of time. In this study, we have evaluated the influence of formali...
PIK3CA Gene Mutations in HNSCC
Cochicho, Daniela; Esteves, Susana; Rito, Miguel; Silva, Fernanda; Martins, Luís; Montalvão, Pedro; Cunha, Mário; Magalhães, Miguel; Gil da Costa, Rui MFunding: This study was financially supported by the Virology Laboratory from the Pathology Department of the Portuguese Oncology Institute of Lisboa IUIC/1168, with contributions by the Research Center of the Portuguese Oncology Institute of Porto (project no. PI86-CI-IPOP-66-2017), by Base Funding-UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology, and Energy—LEPABE—funded b...
Establishment and characterization of a novel ovarian high-grade serous carcino...
Silva, Fernanda; Coelho, Filipa; Peixoto, Ana; Pinto, Pedro; Martins, Carmo; Frombach, Ann Sophie; Santo, Vítor E.; Brito, Catarina; Guimarães, AntónioFunding Information: We acknowledge to Unidade Investigação Patobiologia Molecular (UIPM) facilities and to Pathology Department of Instituto Português de Oncologia Francisco Gentil de Lisboa (IPOLFG). We acknowledge funding from the iNOVA4Health—UIDB/04462/2020 and UIDP/04462/2020, a program financially supported by Fundação para a Ciência e Tecnologia / Ministério da Ciência, Tecnologia e Ensino Superior (FCT...
Exploring Metabolic Signatures of Ex Vivo Tumor Tissue Cultures for Prediction ...
Mendes, Rita; Graça, Gonçalo; Silva, Fernanda; Guerreiro, Ana C L; Gomes-Alves, Patrícia; Serpa, Jacinta; Boghaert, Erwin R; Alves, Paula M; Félix, AnaPredicting patient response to treatment and the onset of chemoresistance are still major challenges in oncology. Chemoresistance is deeply influenced by the complex cellular interactions occurring within the tumor microenvironment (TME), including metabolic crosstalk. We have previously shown that ex vivo tumor tissue cultures derived from ovarian carcinoma (OvC) resections retain the TME components for at lea...
Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by ...
Nunes, Sofia C.; Ramos, Cristiano; Santos, Inês; Mendes, Cindy; Silva, Fernanda; Vicente, João B.; SA, Pereira; Félix, Ana; Gonçalves, Luís G.Funding Information: Funding. This research was supported by Funda??o para a Ci?ncia e Tecnologia (FCT) (Ph.D. ProRegeM program, Ref: PD/BD/105893/2014; FCT individual Ph.D. fellowship Ref: 2020.06956.BD) and iNOVA4 Health (Project 4 and Project 21). iNOVA4Health-UID/Multi/04462/2013 is a program financially supported by Funda??o para a Ci?ncia e Tecnologia/ Minist?rio da Educa??o e Ci?ncia, through national fu...