© The Author(s) 2024. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.; BACKGROUND: We tested whether providing BCG vaccine to healthcare workers (HCWs) could reduce non-planned absenteeism and thereby reduce the potential impact of the COVID-19 pandemic on healthcare systems in Africa. METHODS: We conducted a multicenter, single-blinded, placebo-controlled rando...
UID/SOC/04647/2013; A modernização na agricultura no final da década de 70 do século XX, no Brasil, ajudada pela tecnologia, permitiu ao mercado disponibilizar uma ampla gama de equipamentos tecnológicos para o uso agrícola. Tal causou o avanço agrícola para áreas impróprias para esse tipo de atividade econômica como, por exemplo, a região dos municípios de Jataí e Serranópolis no Estado de Goiás/Brasil. Desde ...
Hypophosphatasia is a rare genetic disease with low tissue nonspeficic alkaline phosphatase activity (TNSALP), due to ALPL gene mutation. There are 6 clinical forms. Childhood form is caractherized by short stature, premature loss of decidous teeth and diffuse bone pain associated with a pathological bone fracture in the past. Laboratory findings present low serum level of alkaline phosphatase and high levels o...
The discovery of the receptor activator of nuclear factor-kB (RANK)/RANK Ligand (RANKL)/osteoprotegerin (OPG) pathway contributed to the understanding of how bone formation and resorption were processed and regulated. RANKL and OPG are members of the tumor necrosis factor (TNF) and TNF receptor (TNFr) superfamilies, respectively, and binding to receptor activator of NF-kB (RANK) not only regulate osteoclast for...
Objective: Rheumatoid Arthritis (RA) disease activity plays an important role in patients' disability A standardized approach to measure it was achieved by using disease activity score (DAS) based on erythrocyte sedimentation rate (ESR) and more recently C-reactive protein (CRP). In this study we will assess the role and influence of ESR and CRP in evaluating and assessing the disease activity. Methods: This is...
Fibrous dysplasia of bone or Jaffe Lischtenstein's disease is a genetic, non-inheritable disease of bone development, characterized by bone pain, deformities and fracture, mainly observed in young adults. The frequency is equal between sexes. Mutations in the gene coding the Gs alpha, GNAS complex, results in osteoblastic differentiation defects, and bone resorption. The disease can have a monostotic or polyost...