5 documents found, page 1 of 1
Blueberry juice as a nutraceutical approach to prevent prediabetes progression ...
Nunes, S.; Viana, S.; Rolo, A.; Palmeira, C.; André, A.; Cavadas, C.; Pintado, M.; Reis, F.
Alterations in phospholipidomic profile in the brain of mouse model of depressi...
Faria, R.; Santana, M. M.; Aveleira, C. A.; Simões, C.; Maciel, E.; Melo, T.; Santinha, D.; Oliveira, M. M.; Peixoto, F.; Domingues, P.; Cavadas, C.Depression is a worldwide disability disease associated with high morbidity and has increased dramatically in the last few years. The differential diagnosis and the definition of an individualized therapy for depression are hampered by the absence of specific biomarkers. The aim of this study was to evaluate the phospholipidomic profile of the brain and myocardium in a mouse model of depression induced by chron...
Neuropeptide Y receptors activation protects rat retinal neural cells against n...
Santos-Carvalho, A.; Elvas, F.; Álvaro, A. R.; Ambrósio, A. F.; Cavadas, C.It has been claimed that glutamate excitotoxicity might have a role in the pathogenesis of several retinal degenerative diseases, including glaucoma and diabetic retinopathy. Neuropeptide Y (NPY) has neuroprotective properties against excitotoxicity in the hippocampus, through the activation of Y1, Y2 and/or Y5 receptors. The principal objective of this study is to investigate the potential protective role of N...
Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy
Álvaro, A. R.; Martins, J.; Costa, A. C.; Fernandes, E.; Carvalho, F.; Ambrósio, A. F.; Cavadas, C.Ecstasy (3,4-methylenedioxymethamphetamine; MDMA) has potent CNS stimulant effects. Besides the acute effects of MDMA, such as psychomotor activation, euphoria, decreased appetite, and hyperthermia, long-term damage of dopaminergic and serotonergic nerve terminals in multiple brain areas have also been reported. Although some studies have demonstrated that considerable amounts of MDMA reach the vitreous humor o...
Pharmacological properties of Tilia europeæ aqueous: screening anxiolytic/sedat...
Cotrim, M. D.; Figueiredo, I. V.; Cavadas, C.; Cunha, A. Proença da; Caramona, M. M.; Macedo, T. R. A.The extracts or infusions obtained from inflorescences of Tilia europeae have been used in popular medicine as a sedative/anxiolytic drug. The purpose of the present work was to evaluate these possible properties of this extract, by using different behavioural models. The extract, orally administered to mice, prolonged sleeping time, changed the level of anxiety, affected curiosity and locomotor activity and sh...