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Investigation of Trypanosoma-induced vascular damage sheds insights into Trypan...

Pereira, Sara Silva; Brás, Daniela; Porqueddu, Teresa; Nascimento, Ana M.; Niz, Mariana De

Multiple blood-borne pathogens infecting mammals establish close interactions with the host vascular endothelium as part of their life cycles. In this work, we investigate differences in the interactions of three Trypanosoma species: T. brucei, T. congolense and T. vivax with the blood vasculature. Infection with these species results in vastly different pathologies, including different effects on vascular home...


Investigation of Trypanosoma-induced vascular damage sheds insights into Trypan...

Pereira, Sara Silva; Brás, Daniela; Porqueddu, Teresa; Nascimento, Ana M.; Niz, Mariana de

Multiple blood-borne pathogens infecting mammals establish close interactions with the host vascular endothelium as part of their life cycles. In this work, we investigate differences in the interactions of three Trypanosoma species: T. brucei, T. congolense and T. vivax with the blood vasculature. Infection with these species results in vastly different pathologies, including different effects on vascular home...


The psychological impact of restorative justice practices on victims of crimes—...

Nascimento, Ana M.; Andrade, Joana; Castro Rodrigues, Andreia de

Background: Restorative justice emerges as a theoretical-practical approach to the criminal legal system, in which the reparation of damage of the victim is a central point. However, the growing empirical production referring to the effects of this approach on victims is sometimes shown to be weakened or dispersed, focusing mainly on their satisfaction. Objective: The present work intended to systematically eva...


Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropi...

De Niz, Mariana; Brás, Daniela; Ouarné, Marie; Pedro, Mafalda; Nascimento, Ana M.; Henao Mišíková, Lenka; Franco, Claudio; Figueiredo, Luisa M.

Trypanosoma brucei is responsible for lethal diseases in humans and cattle in Sub-Saharan Africa. These extracellular parasites extravasate from the blood circulation into several tissues. The importance of the vasculature in tissue tropism is poorly understood. Using intravital imaging and bioluminescence, we observe that gonadal white adipose tissue and pancreas are the two main parasite reservoirs. We show t...


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