5 documents found, page 1 of 1
Strawberry Leaves Extract for Cosmetic Industry
Silva, AP; Rodrigues, B; Bonny, L; Manrique, Y.A.In 2020, Portugal had an average strawberry production of 10 thousand tons, and 15 % was considered strawberry plant residues. This work proposed a new product that uses the compounds extracted from the strawberry residues-stem and leaves, excluding the fruit-as an active ingredient for cosmetic application. Strawberry leaves were extracted with 50 % ethanol. This extract mainly consists of lactic acid, ascorbi...
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology a...
Socodato, R; Portugal, CC; Canedo, T; Rodrigues, A; Almeida, TO; Henriques, JF; Vaz, SH; Magalhães, J; Silva, CM; Baptista, FI; Alves, RLNervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in adult microglia is sufficient to trigger spontaneous microglia activation, producing a neurological phenotype (including synapse and neuron loss, impairment of long-term potentiation [LTP], formation of ß-amyloid plaques, and memory ...
Rational Identification of a Colorectal Cancer Targeting Peptide through Phage ...
Ferreira, D; Silva, AP; Nobrega, FL; Martins, IM; Barbosa-Matos, C; Granja, S; Martins, SF; Baltazar, F; Rodrigues, LRColorectal cancer is frequently diagnosed at an advanced stage due to the absence of early clinical indicators. Hence, the identification of new targeting molecules is crucial for an early detection and development of targeted therapies. This study aimed to identify and characterize novel peptides specific for the colorectal cancer cell line RKO using a phage-displayed peptide library. After four rounds of sele...
Acetabular retroversion: Diagnosis and treatment
Direito-Santos, B; França, G; Nunes, J; Costa, A; Rodrigues, EB; Silva, AP; Varanda, PAcetabular retroversion (AR) consists of a malorientation of the acetabulum in the sagittal plane. AR is associated with changes in load transmission across the hip, being a risk factor for early osteoarthrosis. The pathophysiological basis of AR is an anterior acetabular hyper-coverage and an overall pelvic rotation.The delay or the non-diagnosis of AR could have an impact in the overall management of femoroac...
A intervenção da neuropsicologia num serviço de reabilitação: a propósito de um...
Ribeiro, I; Carvalho, A; Barbeiro, C; Carvalho, F; Ladeira, A; Vera-Cruz, C; Silva, AP; Prates, A