Encontrados 92 documentos, a visualizar página 1 de 10
A contemporary systematic review on deterministic numerical simulations of ligh...
Fernandes, Filipa Gracinda Silva; Sousa, Nuno; Silva, Filipe Samuel; Carvalho, Óscar Samuel Novais; Catarino, Susana OliveiraUnderstanding how light interacts with the head’s tissues is relevant for several biomedical applications. Since in vivo studies involve ethical considerations, numerical simulations have become a recognised alternative method for studying light propagation in biological tissue. Although Monte Carlo methods are the gold standard for these studies, deterministic simulations are becoming more common due to their ...
Sustainable shear wave elastography medical phantoms: waste-based fibrous struc...
Santos, Ana Isabel Zão; Rocha, Sofia Gomes; Fernandes, Nuno Alexandre Tavares Campos; Alves, Diana Isabel Sousa; Ferreira, Diana P.Tissue-mimicking phantoms that accurately replicate human tissue are crucial for validating and optimizing elastography systems and developing new treatment methods. The use of waste-based fibrous structures has the dual benefits of waste reduction and economic viability, mitigating the environmental consequences associated with the textile industry and, thus, posing a particularly interesting avenue of researc...
Ultrasound stimulation increases cartilage synthesis and revert dedifferentiati...
Oliveira, Sofia; Ferreira, Débora Carina Gonçalves Abreu; Padrão, Jorge; Catarino, Susana Oliveira; Monteiro, Francisca Andreia Azevedo; Zille, AndreaTherapeutic ultrasound (US) holds promise as a potential therapy to treat articular cartilage; however, optimized and targeted US protocols are lacking. This study aimed at determining an appropriate set of US protocols for stimulating human chondrocyte activity. Human chondrocytes were exposed to various US parameters, including different central frequencies, power densities, operation modes, pulse parameters,...
Gold nanoparticles synthesized by laser ablation in saline medium: an assessmen...
Ricardo, Philipi Cavalcante; Vanoni, Caio Raphael; Piotrowski, Maurício Jeomar; COSTA, DANIEL COUTINHO; Padrão, Jorge; Zille, Andrea; Satulu, VeronicaGold nanoparticles (AuNPs) produced via pulsed laser ablation in liquids (PLAL) offer significant advantages due to their high purity and absence of ligands. However, their long-term stability is often compromised by aggregation and colloidal destabilization, which are not yet fully understood. This study investigates the influence of different saline agents (NaCl, NaNO3, Na2SO3) and storage conditions on the s...
Experimental validation of time-explicit ultrasound propagation models with sou...
Fernandes, Nuno Alexandre Tavares Campos; Sharma, Shivam; Arieira, Ana Filipa Amorim; Hinckel, Betina; Silva, Filipe SamuelUltrasonic wave attenuation in biological tissues arises from complex interactions between mechanical, structural, and fluidic properties, making it essential to identify dominant mechanisms for accurate simulation and device design. This work introduces a novel integration of experimentally measured tissue parameters into time-explicit nonlinear acoustic wave simulations, in which the equations are directly so...
Development of a hydrophone for measuring the propagation of acoustic waves in ...
Pereira, Anabela; Cardoso, Vanessa Fernandes; Martins, Marcos Silva; Fernandes, Nuno Alexandre Tavares Campos; Carvalho, Óscar Samuel NovaisIn the past years, the prevalence of neurodegenerative diseases has in-creased, highlighting the urgent need to better understand and combat these diseases. Innovative ultrasound treatments have shown promising results but require further investigation, particularly regarding the pene-tration of acoustic waves into the brain. This work focus on developing a hydrophone to study acoustic wave penetration in biolo...
Models for light propagation in the head: trends and implementation of Finite E...
Fernandes, Filipa Gracinda Silva; Silva, Filipe Samuel; Sousa, Nuno; Carvalho, Óscar Samuel Novais; Catarino, Susana OliveiraThe simulation of light propagation in the head tissues has become of interest due to its applicability in transcranial photobiomodulation (tPBM). In silico studies appear as an effective way to research tPBM dosimetry and understand the light reach in the head tissues, as well as potential issues regarding tissue heating. Nonetheless, these computer models are still very simple and come with several limitation...
Unraveling the potential of transcranial photobiomodulation and ultrasound stim...
Fernandes, Nuno Alexandre Tavares Campos; Catarino, Susana Oliveira; Carvalho, Óscar Samuel NovaisThe human brain is the most sophisticated and the finest processing unit ever designed, but mental and neurological disorders are an imminent threat to its functioning. Indeed, brain disorders comprise one of the most challenging health issues of modern society due to their tremendous health, social, and economic impact. However, pharmacological therapies face a physical obstacle – the blood-brain barrier (BBB)...
Mapping and modeling ultrasound propagation for tailored brain therapies
Carvalho, Óscar Samuel NovaisThe work presented here is dedicated to the mapping and modeling of the transmission profiles of optical and mechanical stimuli in the brain, with the ultimate goal of optimizing transcranial stimulation techniques for the treatment of neurological and psychiatric disorders. The presentation highlights the methodology used for acoustic transmission studies in brain tissues. A specialized device was developed fo...
Experimental and in silico models for studying light propagation in the head
Fernandes, Filipa Gracinda Silva; Silva, Filipe Samuel; Sousa, Nuno; Carvalho, Óscar Samuel Novais; Catarino, Susana OliveiraTranscranial photobiomodulation (tPBM) is an alternative therapy to conventional approaches, with clinical studies that show promising results for the treatment of several neurological pathologies, such as stroke and dementia related conditions. Despite its potential, the optimal light parameters and dosimetry for effective tPBM therapy remain uncertain, with most literature on this topic highlighting the need ...