83 documents found, page 1 of 9
Labdanum resin from Cistus ladanifer L. as a source of compounds with anti-diab...
Frazão, David F.; Delgado, F.M.G.; Gonçalves, José Carlos; Gomes, Carlos Martins; Sosa Diaz, Teresa; Silva, Amélia M.Labdanum resin or “gum” can be obtained from Cistus ladanifer L. by two different extraction methods: the Zamorean and the Andalusian processes. Although its main use is in the fragrance and perfumery sectors, ethnobotanical reports describe its use for medicinal purposes in managing hyperglycemia and mental illnesses. However, data concerning the bioactivities and pharmacological applications are scarce. In th...
Modified drug delivery systems for veterinary use: pharmaceutical development a...
Souto, Eliana B.; Barbosa, Catarina I.; Baldim, Iara; Campos, Joana R.; Fernandes, Ana R.; Mazzola, Priscila G.; Andreani, Tatiana; Dias, Isabel R.Scientific research in the field of veterinary pharmacology has provided new opportunities for the development of modified release dosage forms, with the aim to improve therapeutic efficacy and reduce animal stress. The formulation of classical drug molecules with advanced biomaterials has become a new approach to increasing drug bioavailability and improving the therapeutic outcome. The main reasons for the de...
Rockrose land management : contribution of periodic harvesting to increase valu...
Frazão, David F.; Gonçalves, José Carlos; Silva, Amélia M.; Delgado, F.M.G.: Cistus ladanifer L. (Cistaceae) occupies extensive areas as a dominant species (shrublands) or is associated to other major forest typologies in the Iberian Peninsula. Cistus ladanifer shrublands are mostly present in oligotrophic lands with little valorisation and management and as they develop over the years (up to 20-years-old) they promote the ignition and perpetuation of fire. To contribute to the proper...
Labdanum resin from Cistus ladanifer L. : evaluation of residual water vs. extr...
Frazão, David F.; Mesquita, Maria da Conceição; Silva, Helena; Silva, Amélia M.; Gonçalves, José CarlosCistus ladanifer L. (Cistaceae) is an endemic and abundant resource in the Iberian Peninsula and North Africa. This plant exudes an aromatic resin nowadays valued in the perfumery and fragrance industry. Traditional processes for the extraction and isolation of such resin use boiling water or alkaline water followed by acidic precipitation. However, a concern arises about the effluents resulting from these extr...
Physicochemical and biopharmaceutical aspects influencing skin permeation and r...
Souto, Eliana; Fangueiro, Joana F.; Fernandes, Ana R.; Cano, Amanda; Sanchez-Lopez, Elena; Garcia, Maria L.; Severino, Patrícia; Paganelli, Maria O.The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective barrier, against the entry of foreign substances and against the excessive loss of endogenous material. Human skin impose...
Physicochemical and biopharmaceutical aspects influencing skin permeation and r...
Souto, Eliana B.; Fangueiro, Joana F.; Fernandes, Ana R.; Cano, Amanda; Sanchez-Lopez, Elena; Garcia, Maria L.; Severino, Patrícia; Paganelli, Maria O.The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective barrier, against the entry of foreign substances and against the excessive loss of endogenous material. Human skin impose...
Sol-gel carrier system: A novel controlled drug delivery
Andreani, Tatiana; De Souza, Ana Luiza R. [UNESP]; Silva, Amélia M.; Souto, Eliana B.Made available in DSpace on 2022-04-28T19:02:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-10-01; In the recent decades, numerous drug delivery systems based on nanoparticles have been developed. To deliver drugs to a specific site, many vehicles have been designed, including liposomes, lipid and polymeric nanoparticles. However these systems can suffer some limitations such as thermal and physical ...
Cistus ladanifer L. tissue culture from leaf and stem explants.
Frazão, David F.; Delgado, F.M.G.; Gonçalves, José Carlos; Barroca, Celina; Silva, Amélia M.Cistus ladanifer L. exudes a phenolic and terpenoid resin with interesting bioactive and aromatic properties. Despite its high abundance in the wild, this plant can be cultivated to advantage on oligotrophic and trace-elements contaminated soils. Plant tissue culture may be used to produce specific metabolites or for clonal propagation of specific genotypes for plantation. From a biotechnological perspective th...
Major anthocyanins in elderberry effectively trap methylglyoxal and reduce cyto...
Ferreira, Sandrine S.; Domingues, M. Rosário; Barros, Cristina; Santos, Sónia A.O.; Silvestre, Armando J.D.; Silva, Amélia M.; Nunes, Fernando M.The accumulation of advanced glycation end-products (AGEs) in the body is implicated in numerous diseases, being methylglyoxal (MGO) one of the main precursors. One of the strategies to reduce AGEs accumulation might be acting in an early stage of glycation by trapping MGO. Thus, this work aimed to evaluate, for the first time, the potential of elderberries polyphenols to trap MGO, access the formation of MGO a...
Hydrogels for modified-release drug delivery systems
Zielinska, Aleksandra; Eder, Piotr; Rannier, Lucas; Cardoso, Juliana C.; Severino, Patrícia; Silva, Amélia M.; Souto, Eliana B.Hydrogels for the modified-release drug delivery systems is a continuously growing area of interest for the pharmaceutical industry. According to the global market, the use of polymers in this area is projected to reach $31.4 million by 2027. This review discusses the recent advances and perspectives of hydrogel in drug delivery systems for oral, parenteral, nasal, topical, and ophthalmic. The search strategy d...