11 documents found, page 1 of 2
Uncaria tomentosa (Willd. ex Schult.): Focus on Nutraceutical Aspects
Nazhand, Amirhossein; Durazzo, Alessandra; Lucarini, Massimo; Silva, Amelia M.; Souto, Selma B.; Severino, Patricia; Souto, Eliana Maria BarbosaMedicinal plants have been globally exploiting as an alternative to chemical drugs in the treatment of several diseases due to low unwanted side effects, environmentally friendly nature, and low production costs. Therefore, it is important to analyze the therapeutic properties of various medicinal plants to understand their potential bioactivity. Uncaria tomentosa is one of these medicinal plants with many heal...
Permeability, anti-inflammatory and anti-VEGF profiles of steroidal-loaded cati...
Fernandes, Ana R.; Santos, Tiago dos; Granja, Pedro L.; Sanchez-Lopez, Elena; Garcia, Maria L.; Silva, Amelia M.; Souto, Eliana B.Age-related macular degeneration (AMD) is defined as a degenerative, progressive and multifactorial disorder that affects the macula with a complex etiology. The retinal pigment epithelium is a monolayer of cells that has the function to separate the surface of the choroid from the neural retina that is involved in the signal transduction leading to vision. The blood-aqueous barrier and the blood retinal barrie...
Exudative versus nonexudative age-related macular degeneration: Physiopathology...
Fernandes, Ana Rita; Zielinska, Aleksandra; Sanchez-Lopez, Elena; dos Santos, Tiago; Garcia, Maria Luisa; Silva, Amelia M.; Karczewski, JacekAge-related macular degeneration (AMD) is an eye disease typically associated with the aging and can be classified into two types—namely, the exudative and the nonexudative AMD. Currently available treatments for exudative AMD use intravitreal injections, which are associated with high risk of infection that can lead to endophthalmitis, while no successful treatments yet exist for the nonexudative form of AMD. ...
Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and histor...
Durazzo, Alessandra; Nazhand, Amirhossein; Lucarini, Massimo; Silva, Amelia M.; Souto, Selma B.; Guerra, Fabrizia; Severino, PatriciaMedicinal plants always are part of folk medicine and are nowadays receiving worldwide attention for prophylaxis, management, and treatment of several diseases, as an alternative to chemical drugs. The current work provided a comprehensive overview and analysis of the Astragalus and health relationship in literature. The analysis of their therapeutic potential is thus instrumental to understand their bioactivit...
Vitex agnus-castus L.: main features and nutraceutical perspectives
Souto, Eliana B.; Durazzo, Alessandra; Nazhand, Amirhossein; Lucarini, Massimo; Zaccardelli, Massimo; Souto, Selma B.; Silva, Amelia M.Medicinal plants are used worldwide due to their lower risk of side effects and eco-friendly, cost-effective production when compared to chemical drugs, encouraging researchers to further exploit the therapeutic potential of the former. One of the most popular medicinal plants is Vitex agnus-castus L., grown in tropical and sub-tropical regions, to which different health benefits have already been attributed. I...
Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome-Review...
Vieira, Raquel; Souto, Selma B.; Sánchez-López, Elena; Machado, Ana López; Severino, Patrícia; Jose, Sajan; Santini, Antonello; Fortuna, A.Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia together with disturbances in the metabolism of carbohydrates, proteins and fat, which in general results from an insulin availability and need imbalance. In a great number of patients, marketed anti-glycemic agents have shown poor effectiveness in maintaining a long-term glycemic control, thus being associated with severe adv...
Clotrimazole-Loaded Mediterranean Essential Oils NLC: A Synergic Treatment of C...
Carbone, Claudia; Teixeira, Maria do Céu; Sousa, Maria Céu; Martins-Gomes, Carlos; Silva, Amelia M.; Souto, Eliana Maria Barbosa; Musumeci, TeresaThe increasing development of resistance of Candida species to traditional drugs represents a great challenge to the medical field for the treatment of skin infections. Essential oils were recently proposed to increase drug effectiveness. Herein, we developed and optimized (23 full factorial design) Mediterranean essential oil (Rosmarinus officinalis, Lavandula x intermedia "Sumian", Origanum vulgare subsp. hir...
Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial ...
Campos, Joana R.; Fernandes, Ana R.; Sousa, Raquel; Fangueiro, Joana F.; Boonme, Prapaporn; Garcia, Maria Luisa; Silva, Amelia M.; Naveros, Beatriz C.The aim of this work is development of a nontoxic, long-term stable solid lipid nanoparticles (SLN) formulation for the loading of Nimesulide (NiM) by a 22 factorial design. The optimized formulation was composed of 10wt% of glyceryl behenate and 2.5wt% of poloxamer 188. Immediately after production, Z-Ave of NiM-SLN was 166.1±0.114nm, with a polydispersity index (PI) of 0.171±0051 and zeta potential nearly neu...
Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome - revi...
Vieira, Raquel; Souto, Selma B.; Sánchez-López, Elena; Machado, Ana López; Severino, Patricia; Jose, Sajan; Santini, Antonello; Fortuna, AnaDiabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia together with disturbances in the metabolism of carbohydrates, proteins and fat, which in general results from an insulin availability and need imbalance. In a great number of patients, marketed anti-glycemic agents have shown poor effectiveness in maintaining a long-term glycemic control, thus being associated with severe adv...
Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrateg...
Vieira, Raquel; Souto, Selma B.; Sánchez-López, Elena; López Machado, Ana; Severino, Patricia; Jose, Sajan; Santini, Antonello; Silva, Amelia M.Diabetes is a complex disease characterized by hyperglycemia, together with polyuria, polydipsia, and polyphagia. While Type 1 diabetes mellitus (T1DM) results from genetic, environmental, or immune dysfunction factors leading to pancreatic ß-cell destruction depriving the organism from endogenous insulin, Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance. Depending on the type o...