196 documents found, page 1 of 20
Optimized in-solution enrichment over a million ancient human SNPs
Davidson, Roberta; Roca-Rada, Xavier; Ravinshakar, Shyamsundar; Taufik, Leonard; Haarkötter, Christian; Collen, Evelyn; Williams, Matthew P.Background In-solution hybridization enrichment of genetic markers is a method of choice in paleogenomic studies, where the DNA of interest is generally heavily fragmented and contaminated with environmental DNA, and where the retrieval of genetic data comparable between individuals is challenging. Here, we benchmark the commercial “Twist Ancient DNA” reagent from Twist Biosciences using sequencing libraries fr...
The genetic history of Portugal over the past 5.000 years
Roca-Rada, Xavier; Davidson, Roberta; Williams, Mathew P.; Villalba Mouco, Vanessa; Carvalho, António faustino; Ravinshakar, Shyamsundar; Collin, EvelynBackground Recent ancient DNA studies uncovering large-scale demographic events in Iberia have presented very limited data for Portugal, a country located at the westernmost edge of continental Eurasia. Here, we present the most comprehensive collection of Portuguese ancient genome-wide data, from 67 individuals spanning 5000 years of human history, from the Neolithic to the nineteenth century. Results We ident...
The genetic history of Portugal over the past 5,000 years.
Roca-Rada, Xavier; Davidson, Roberta; Williams, Matthew P.; Villalba-Mouco, Vanessa; Carvalho, António Manuel Faustino de; Ravishankar, ShyamsundarRecent ancient DNA studies uncovering large-scale demographic events in Iberia have presented very limited data for Portugal, a country located at the westernmost edge of continental Eurasia. Here, we present the most comprehensive collection of Portuguese ancient genome-wide data, from 67 individuals spanning 5000 years of human history, from the Neolithic to the nineteenth century. We identify early admixture...
Relatório Final do projeto ALOP (ALT20-03-0145-FEDER-000004)
Salgado, Rui; Palma, Patrícia; Morais, M. Manuela; Almeida, Adelaide; Alvarenga, Paula; Antunes, Célia; Aranha, Sergio; Bárias, Samuel; Barrenho, JoelO Projeto ALOP teve início formal a 25 de Maio de 2016 e terminou a 31 de dezembro de 2019. Neste relatório final procuramos dar conta das atividades efetuadas e principalmente dos resultados obtidos. A tarefa está facilitada pois o projeto, em conjunto com as sinergias geradas com outros projetos e as colaborações nacionais e internacionais dos vários membros da equipa permitiram a publicação de um invejável n...
Population genomics of post-glacial western Eurasia
Allentoft, Morten E.; Sikora, Martin; Refoyo-Martínez, Alba; Irving-Pease, Evan K.; Fischer, Anders; Barrie, William; Ingason, Andrés; Stenderup, JesperWestern Eurasia witnessed several large-scale human migrations during the Holocene1,2,3,4,5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses rev...
An Experimental Approach to Address the Functional Relationship between Antioxi...
Mendes, Daniela Sofia Sequeira; Silva, Ana Maria; Oliveira, Maria Manuel; Andrade, Paula B.; Videira, Romeu AntónioMitochondrial dysfunction and cytosolic oxidative stress are pathological biomarkers interlinked in several chronic diseases and cellular toxicity promoted by high-energy radiation or xenobiotics. Thus, assessing the activities of the mitochondrial redox chain complexes and the cytosolic antioxidant enzymes in the same cell culture system is a valuable approach to addressing the challenge of chronic diseases or...
Perceived employability in a situation of crisis: The influence of the external...
Silva, Ana Maria; Gomes, Jorge Filipe da Silva; Monteiro, SílviaPurpose This study aims to analyse how people's perceived employability was affected during the coronavirus disease 2019 (COVID-19) pandemic. This study explores individuals' perceived financial threat, age and work situation as factors that shape perceived employability. Design/methodology/approach Data were collected via a survey at three different times between October 2020 and May 2021, which were chosen to...
Mycobacterium leprae diversity and population dynamics in medieval Europe from ...
Pfrengle, Saskia; Neukamm, Judith; Guellil, Meriam; Keller, Marcel; Molak, Martyna; Avanzi, Charlotte; Kushniarevich, Alena; Montes, NúriaBACKGROUND: Hansen's disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in historical records, its origins and past dissemination patterns are still widely unknown. Applying ancient DNA approaches to its major causative agent, Mycobacterium leprae, can significant...
Dams: Impacts and Hazards
Silva, Ana Maria; Araújo, Alexandre; Bezzeghoud, Mourad; Rosa, Rui; Salgado, RuiIn the first year of operation of the biggest artificial lake of Europe, Alqueva, which is still in a refilling period, this meeting aims to evaluate the negative and positive impacts of this kind of impoundment. Invited scientists and experts, who belong to a wide variety of scientific areas, with a broad range of viewpoints about this subject, will give an embraced overview about impacts and hazards of dams a...
An integrative skeletal and paleogenomic analysis of stature variation suggests...
Marciniak, Stephanie; Bergey, Christina M.; Silva, Ana Maria; Hałuszko, Agata; Furmanek, Mirosław; Veselka, Barbara; Velemínský, PetrHuman culture, biology, and health were shaped dramatically by the onset of agriculture ∼12,000 y B.P. This shift is hypothesized to have resulted in increased individual fitness and population growth as evidenced by archaeological and population genomic data alongside a decline in physiological health as inferred from skeletal remains. Here, we consider osteological and ancient DNA data from the same prehistor...