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Human Bone Marrow Mesenchymal Stromal/Stem Cells Regulate the Proinflammatory R...
Laranjeira, Paula; Pedrosa, Mónia; Duarte, Cátia; Pedreiro, Susana; Antunes, Brígida; Ribeiro, Tânia; Dos Santos, Francisco; Martinho, AntónioRheumatoid arthritis (RA) is a disabling autoimmune disease whose treatment is ineffective for one-third of patients. Thus, the immunomodulatory potential of mesenchymal stromal/stem cells (MSCs) makes MSC-based therapy a promising approach to RA. This study aimed to explore the immunomodulatory action of human bone marrow (BM)-MSCs on myeloid dendritic cells (mDCs) and monocytes, especially on cytokines/chemok...
Analysis of oxidised and glycated aminophospholipids: complete structural chara...
Colombo, Simone; Criscuolo, Angela; Zeller, Martin; Fedorova, Maria; Domingues, M Rosário; Domingues, PedroThe aminophospholipids (APL), phosphatidylethanolamine (PE) and phosphatidylserine (PS) are widely present in cell membranes and lipoproteins. Glucose and reactive oxygen species (ROS), such as the hydroxyl radical (•OH), can react with APL leading to an array of oxidised, glycated and glycoxidised derivatives. Modified APL have been implicated in inflammatory diseases and diabetes, and were identified as signa...
Modulation of the inflammatory response of immune cells in human peripheral blo...
Colombo, Simone; Martín-Sierra, Carmen; Melo, Tânia; Laranjeira, Paula; Paiva, Artur; Domingues, Pedro; Domingues, M RosárioAminophospholipids (APL), phosphatidylethanolamine (PE) and phosphatidylserine (PS), can be oxidized upon oxidative stress. Oxidized PE and PS have been detected in clinical samples of different pathologies and may act as modulators of the inflammatory response. However, few studies have focused on the effects of oxidized APL (ox-APL) esterified with arachidonic acid, even though a considerable number of studie...