119 documents found, page 1 of 12
Devices for curb-climbing wheelchairs
Silva, Ana Rita; Camacho, Benedita; Costa, António NicolauThe lack of accessibility to public spaces and basic essential services for individuals with reduced mobility, whether temporary or permanent, poses challenges for general citizens, particularly those in wheelchairs. Differences in ground levels, architectural obstacles, and land obstructions are just a few examples of the difficulties these individuals encounter daily. This study aims to understand the needs o...
Determinants of HIV-1 Transmission Clusters and Transmitted Drug Resistance in ...
Abrantes, Ricardo; Pimentel, Victor; Sebastião, Cruz; Miranda, Mafalda N S; Seabra, Sofia; Silva, Ana Rita; Diniz, António; Ascenção, BiancaIntroduction: In the EU/EEA, men who have sex with men (MSM) is a priority group for the prevention and control of HIV-1 infection. In Portugal, the 2023 HIV incidence rate was 8.2 per 100,000 inhabitants, with 876 new infections, 41.7% in MSM. We aim to characterize HIV-1 transmission clusters (TC) and transmitted drug resistance (TDR) and its sociodemographic, behavioral, clinical, and viral genomic determina...
Feline Infectious Peritonitis Effusion Index: A Novel Diagnostic Method and Val...
Lopes, Ricardo; Sampaio, Filipe; Lima de Carvalho, Hugo; Garcês, Andreia; Fernandes, Cátia; Neves, Carolina Vitória; Sardinha de Brito, AlexandreThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led the medical and scientific community to explore the pathogenesis and clinical manifestations of coronaviruses. In felines, a widespread coronavirus known as feline coronavirus (FCoV) can lead to feline infectious peritonitis (FIP), a highly fatal disease characterised by severe systemic inflammation. Diagnosing FCoV remains ch...
Determinants of HIV-1 transmission clusters and transmitted drug resistance in ...
Abrantes, Ricardo; Pimentel, Victor; Sebastião, Cruz; Miranda, Mafalda N. S.; Seabra, Sofia; Silva, Ana Rita; Diniz, António; Ascenção, BiancaIn the EU/EEA, men who have sex with men (MSM) is a priority group for the prevention and control of HIV-1 infection. In Portugal, the 2023 HIV incidence rate was 8.2 per 100,000 inhabitants, with 876 new infections, 41.7% in MSM. We aim to characterize HIV-1 transmission clusters (TC) and transmitted drug resistance (TDR) and its sociodemographic, behavioral, clinical, and viral genomic determinants in MSM new...
Family needs in the organ and tissue donation process: scoping review
Silva, Ana Rita; Nunes, Nísia; Veludo, Filipa; Miguel, SusanaIntroduction: The process of organ and tissue transplantation has achieved success through its remarkable and swift advances, given that the technical and scientific progress recorded in the last decades in the field of medicine has made it possible to improve significantly the therapeutic possibilities and quality of life of the organ recipient. During the donation process, the organ donor’s family experiences...
SAFETY AND EFFICACY OF DOLUTEGRAVIR BASED TRIPLE THERAPY IN HIV-2 INFECTION
Lopes, Maria João; Pacheco, Patrícia; Marques, Nuno; Mansinho, Kamal; Araújo, Vânia; Janeiro, Nuno; Lopes, Cristina; Rodrigues, Paulo; Maltez, FernandoDatabase solution for an HIV-2 cohort study Publication "Real-world experience of TAF/FTC/BIC in people with HIV-2" presented at European AIDS Clinical Society Conference, Oct 2023, Warsaw HIV-2 salvage therapy with Lenacapavir (injectable, capsid inhibitor, EMA approved 2022)
Determinants of HIV late presentation among men who have sex with men in Portug...
Abrantes, Ricardo; Pimentel, Victor; Miranda, Mafalda N. S.; Silva, Ana Rita; Diniz, António; Ascenção, Bianca; Piñeiro, Carmela; Koch, CarmoIntroduction: HIV late presentation (LP) remains excessive in Europe. We aimed to analyze the factors associated with late presentation in the MSM population newly diagnosed with HIV in Portugal between 2014 and 2019. Methods: We included 391 newly HIV-1 diagnosed Men who have Sex with Men (MSM), from the BESTHOPE project, in 17 countrywide Portuguese hospitals. The data included clinical and socio-behavioral q...
Bee Venom-Loaded Niosomes as Innovative Platforms for Cancer Treatment: Develop...
Pinto, Maria Beatriz; Pires, Patrícia C.; Calhelha, Ricardo C.; Silva, Ana Rita; Sousa, Maria João; Vilas-Boas, Miguel; Falcão, Soraia; Veiga, FranciscoDespite past efforts towards therapeutical innovation, cancer remains a highly incident and lethal disease, with current treatments lacking efficiency and leading to severe side effects. Hence, it is imperative to develop new, more efficient, and safer therapies. Bee venom has proven to have multiple and synergistic bioactivities, including antitumor effects. Nevertheless, some toxic effects have been associate...
Response surface methodology and artificial neural network modeling as predicti...
Silva, Ana Rita; Ayuso, Manuel; Oludemi, Taofiq; Gonçalves, Alexandre; Melgar Castañeda, Bruno; Barros, LillianThis study optimized the extraction of three major phenolic compounds (oleuropein, tyrosol, and verbascoside) from olive pomace using microwave- and ultrasonic-assisted methods. Screening factorial design (SFD) and central composite design (CCD) were employed, and response surface methodology (RSM) and artificial neural networks (ANN) were used for data modeling. The microwave-assisted method in the SFD yielded...
Unveiling the metabolites underlying the skin anti-ageing properties of Cytinus...
Silva, Ana Rita; Ayuso, Manuel; García, Pablo A.; Barros, Lillian; Edrada-Ebel, RuAngelieThe genus Cytinus, recognised as one of the most enigmatic in the plant kingdom, has garnered attention for its bioactive potential, particularly its skin anti-ageing properties. Despite this recognition, much remains to be accomplished regarding deciphering and isolating its most active compounds. Hypothesis: This study aimed to identify the compounds responsible for C. hypocistis skin anti-ageing potential. M...