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Somatic mutations in solid tumors: a spectrum at the service of diagnostic arma...
Rossi, Esther Diana; Martini, Maurizio; Bizzarro, Tommazzo; Schmitt, Fernando; Longatto Filho, Adhemar; Larocca, Luigi MariaThis review article deals with the analysis and the detection of the morphological features associated with somatic mutations, mostly BRAF(V600E) mutation, on both cytological and histological samples of carcinomas. Few authors demonstrated that some architectural and specific cellular findings (i.e. polygonal eosinophilic cells defined as "plump cells" and sickle-shaped nuclei) are able to predict BRAF (V600E)...
The expression of monocarboxylate transporters in thyroid carcinoma can be asso...
Rossi, Esther Diana; Bizzarro, Tommaso; Granja, Sara Costa; Martini, Maurizio; Capodimonti, Sara; Luca, Emilia; Fadda, Guido; Lombardi, Celestino PioBRAF (V600E) mutation, usually performed by DNA techniques, is one of the most common diagnostic markers in papillary thyroid carcinoma. Few papers have demonstrated that plump cells (eosinophilic cytoplasms and papillary thyroid carcinoma nuclei) and peculiar sickle-shaped nuclei represent morphological features of BRAF (V600E) on papillary thyroid carcinomas. These features seem to be linked to glycolytic phe...
The role of liquid-based cytology and ancillary techniques in pleural and peric...
Rossi, Esther Diana; Bizzarro, Tommaso; Schmitt, Fernando; Longatto Filho, AdhemarBACKGROUND: Fine-needle aspiration cytology (FNAC) of serous membrane effusions may fulfil a challenging role in the diagnostic analysis of both primary and metastatic disease. From this perspective, liquid-based cytology (LBC) represents a feasible and reliable method for empowering the performance of ancillary techniques (ie, immunocytochemistry and molecular testing) with high diagnostic accuracy. METHODS: I...
The diagnostic and prognostic role of liquid-based cytology: are we ready to mo...
Rossi, Esther Diana; Bizzarro, Tommaso; Longatto Filho, Adhemar; Gerhard, Rene; Schmitt, FernandoHere, we evaluate the diagnostic and prognostic role of liquid-based cytology (LBC) in different body lesions, including thyroid, lung, effusions and malignant breast lesions. LBC has gained consensus after being applied to both non-gynecologic and fine-needle aspiration cytology. Although some remain sceptical regarding the diagnostic efficacy of LBC, mainly when used alone, in recent years, good results have ...